Colloquium on Molecular Kinesis in Cellular Function and Plasticity -- National Academy of Sciences -- Contents -- Colloquium Molecular kinesis in cellular function and plasticity -- MOLECULAR MOTORS -- TRANSLATION INITIATION -- LOCALIZED RNAS -- NEURONAL PLASTICITY -- Colloquium Kinesin molecular motors: Transport pathways, receptors, and human disease -- LESSONS FROM GREEN ALGAE: POSSIBLE LINKS OF INTRAFLAGELLAR TRANSPORT TO HUMAN DISEASE -- LESSONS FROM FRUIT FLIES: ANTEROGRADE AXONAL TRANSPORT AND MITOGEN-ACTIVATED PROTEIN KINASE SIGNALING -- LESSONS FROM HUMANS: FROM ALZHEIMER'S DISEASE TO KINESIN-I RECEPTORS -- KINESIN RECEPTORS AND KINESIN REGULATION -- A SPECULATIVE PROPOSAL FOR THE RELATIONSHIP OF AXONAL TRANSPORT TO THE INITIATION OF ALZHEIMER'S DISEASE -- CONCLUDING REMARKS -- Colloquium All kinesin superfamily protein, KIF, genes in mouse and human -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- Colloquium Assembly and transport of a premessenger RNP particle -- VISUALIZATION OF ASSEMBLY AND TRANSPORT OF BR PARTICLES -- APPROACH TO STUDY BR RNA-BINDING PROTEINS -- SPLICEOSOME ASSEMBLY AND DISASSEMBLY -- PROTEINS CONFINED TO THE NUCLEUS -- PROTEINS ACCOMPANYING THE MRNA INTO THE CYTOPLASM -- THE COTRANSCRIPTIONAL LOADING STAGE -- CONCLUSIONS -- Colloquium Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome -- Colloquium Spatial and temporal control of RNA stability -- TEMPORAL CONTROL OF MATERNAL RNA STABILITY IN DROSOPHILA -- GENETIC CONTROL OF MATERNAL RNA STABILITY IN DROSOPHILA -- CONTROL OF RNA STABILITY IN A SOMATIC CELL LINEAGE -- EVOLUTIONARY CONSERVATION OF DEGRADATION-PROTECTION MECHANISMS -- FUNCTIONS OF TRANSCRIPT DEGRADATION AND PROTECTION -- CONCLUSIONS -- Colloquium Molecular mechanisms of translation initiation in eukaryotes.

Colloquium The target of rapamycin (TOR) proteins -- RAPAMYCIN INHIBITS LONG-TERM FACILITATION -- RAPAMYCIN AND TOR -- TOR SIGNALING -- TOR SIGNALING MODULATES THE PHOSPHORYLATION STATE OF PROTEINS INVOLVED IN TRANSLATIONAL CONTROL -- TOR REGULATES THE ABUNDANCE OF THE TRANSLATION MACHINERY -- TOR AS A MASTER SWITCH FOR CATABOLISM VS. ANABOLISM -- HOW MIGHT TOR SIGNALING BE INVOLVED IN LEARNING AND MEMORY? -- TOR ACTIVITY IS REQUIRED FOR MURINE FOREBRAIN DEVELOPMENT -- SUMMARY AND FUTURE PROSPECTS -- Colloquium The physiological significance of B-actin mRNA localization in determining cell polarity and directional motility -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture -- METHODS -- RESULTS -- DISCUSSION -- Colloquium Molecular organization of the postsynaptic specialization -- THE NMDA RECEPTOR-PSD-95 COMPLEX -- REGULATED SYNAPTIC TARGETING OF AMPA RECEPTORS -- CONCLUDING REMARKS -- Colloquium A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites -- INDUCTION AND DENDRITIC TARGETING OF ARC MRNA AFTER INTENSE NEURONAL ACTIVITY -- NEWLY SYNTHESIZED ARC MRNA IS SELECTIVELY TARGETED TO SYNAPSES THAT HAVE RECENTLY BEEN ACTIVATED -- ARC MRNA IS TARGETED TO DIFFERENT DENDRITIC DOMAINS DEPENDING ON THE POPULATION OF SYNAPSES THAT ARE ACTIVATED -- THE SELECTIVITY OF LOCALIZATION INVOLVES TARGETING OF MRNA TO ACTIVE DOMAINS AND MIGRATION/DEPLETION FROM INACTIVE REGIONS -- LOCALIZATION OF ARC MRNA IN ACTIVATED DENDRITIC LAMINAE IS ASSOCIATED WITH A LOCAL ACCUMULATION OF ARC PROTEIN -- ARC PROTEIN IS ASSEMBLED INTO THE POSTSYNAPTIC DENSITY (PSD)/N-METHYL-D-ASPARTATE (NMDA) RECEPTOR COMPLEX (NRC).

LOCAL PROTEIN SYNTHESIS: A MECHANISM MEDIATING COTRANSLATIONAL ASSEMBLY OF CERTAIN MOLECULES INTO THE SJC/NRC? -- RIBOSOMES AT THE PSD? -- LESSONS FROM THE STUDY OF ARC. A CANDIDATE MECHANISM FOR PROTEIN SYNTHESIS-DEPENDENT SYNAPTIC MODIFICATION -- Colloquium Think globally, translate locally: What mitotic spindles and neuronal synapses have in common -- THE BACKGROUND -- LOCAL TRANSLATIONAL CONTROL AT THE MITOTIC APPARATUS -- LOCAL TRANSLATIONAL CONTROL AT SYNAPSES -- EXTANT QUESTIONS -- Colloquium Vasopressin mRNA localization in nerve cells: Characterization of cis-acting elements and trans-acting factors -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CHARACTERIZATION OF DENDRITIC LOCALIZER SEQUENCES WITHIN VP MRNA -- Colloquium Local translation of classes of mRNAs that are targeted to neuronal dendrites -- MRNA COMPLEXITY OF INDIVIDUAL NEURONAL DENDRITES -- FORMAL MOLECULAR PROOF OF PROTEIN TRANSLATION IN DENDRITES AND IDENTIFICATION OF IN VIVO TRANSLATION ... -- DISCOVERY OF A SECOND MESSENGER SYSTEM IN DENDRITES -- DEMONSTRATION OF SYNTHESIS AND MEMBRANE INSERTION OF INTEGRAL MEMBRANE PROTEINS IN ISOLATED DENDRITES -- SUMMARY -- Colloquium Cytoskeletal microdifferentiation: A mechanism for organizing morphological plasticity in dendrites -- METHODS -- RESULTS -- DISCUSSION -- Colloquium Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation -- FUNCTIONAL SIGNIFICANCE OF ACTIONS OF ESTRADIOL IN THE HIPPOCAMPUS -- EXCITATORY SYNAPSE FORMATION IN THE HIPPOCAMPUS -- NUCLEAR ESTROGEN RECEPTORS IN THE HIPPOCAMPUS -- CELL CULTURE MODEL OF SYNAPSE FORMATION -- NON-NUCLEAR ESTROGEN RECEPTORS -- CELLULAR AND MOLECULAR EVENTS ASSOCIATED WITH SYNAPSE FORMATION -- ROLE OF PROGESTERONE IN SYNAPSE DOWN-REGULATION -- CONCLUSIONS: A MODEL OF ESTROGEN ACTION.

Colloquium Synaptic regulation of protein synthesis and the fragile X protein -- EVIDENCE FOR A ROLE OF SYNAPTIC PROTEIN SYNTHESIS IN SYNAPTOGENESIS -- Molecular Kinesis in Cellular Function and Plasticity.