Self-Perpetuating Structural States in Biology, Disease, and Genetics -- Copyright -- Contents -- Colloquium Self-perpetuating structural states in biology, disease, and genetics -- Colloquium Transmission of prions -- "NATURAL" TRANSMISSION OF PRIONS -- IATROGENIC TRANSMISSION OF PRIONS -- EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS -- CONCLUDING REMARKS -- Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Interactions among prions and prion "strains" in yeast -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by… -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Chaperoning brain degeneration -- MATERIALS AND METHODS -- A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE -- THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY -- CHAPERONE SUPPRESSION OF Α-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASE -- ENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE -- DISCUSSION -- Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity -- MECHANISM OF POLYQ AGGREGATION -- RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY -- TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION -- ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY -- ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITY -- PERSPECTIVES -- Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- CONCLUSION.

Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity -- METHODS -- RESULTS AND DISCUSSION -- Colloquium The insulation of genes from external enhancers and silencing chromatin -- AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT -- INSULATORS AS BARRIERS -- CONCLUSION -- Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion… -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Heritable chromatin structure: Mapping "memory" in histones H3 and H4 -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Does heterochromatin protein 1 always follow code? -- HP1 FOLLOWS CODE -- ARE THERE MULTIPLE MECHANISMS FOR HP1 ASSOCIATION? -- HP1 INTERACTS WITH A MYRIAD OF PROTEINS -- HP1 REGULATES GENE EXPRESSION -- Colloquium Self-perpetuating epigenetic pili switches in bacteria -- CIS- AND TRANS-ACTING PAP SWITCH COMPONENTS -- PAP PHASE VARIATION MODEL -- SWITCH INPUTS -- OUTPUTS -- Colloquium Histone H3 variants specify modes of chromatin assembly -- H3 VARIANTS DETERMINE THE NUCLEOSOME ASSEMBLY PATHWAY -- CENTROMERES REPLICATE BEFORE THEIR SURROUNDING HETEROCHROMATIN -- HIGH-RESOLUTION MAPPING OF CENTROMERE REPLICONS -- INFERRING THE RI MACHINERY -- OPENING A SPACE FOR HISTONE REPLACEMENT -- THE RI TARGET SITES FOR H3 VARIANTS ARE IN DISTINCT NUCLEAR COMPARTMENTS -- WHY RI ASSEMBLY? -- CONCLUSIONS -- Colloquium Induction and maintenance of nonsymmetrical DNA methylation in Neurospora -- MAINTENANCE METHYLATION IN NEUROSPORA -- CLUES TO INVOLVEMENT OF METHYL/RIP-DNA BINDING PROTEINS AND HISTONE DEACETYLATION IN DNA METHYLATION.

THE DIM-5 HISTONE METHYLTRANSFERASE INTEGRATES HISTONE CODE INFORMATION AND CONTROLS DNA METHYLATION -- Colloquium Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium RNA-directed DNA methylation in Arabidopsis -- EXPERIMENTAL PROCEDURES -- RESULTS -- DISCUSSION -- Self-Perpetuating Structural States in Biology, Disease, and Genetics.