Adverse Events Associated with CHILDHOOD VACCINES -- Copyright -- Preface -- Acknowledgments -- Contents -- 1 Executive Summary -- BACKGROUND AND HISTORY -- THE CHARGE TO THE COMMITTEE -- THE STUDY PROCESS -- CAUSALITY AND WEIGHT OF EVIDENCE -- NEED FOR RESEARCH AND SURVEILLANCE -- REFERENCES -- 2 Causality and Evidence -- CAUSALITY -- Definitions -- Types of Causal Questions -- Can It? -- Did It? -- Will It? -- SOURCES OF EVIDENCE FOR CAUSALITY -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Combining the Evidence -- SUMMARIZING THE EVIDENCE FOR CAUSALITY -- REFERENCES -- 3 Neurologic Disorders -- DEMYELINATING DISEASE -- Experimental Models -- Acute Disseminated Encephalomyelitis -- Multiple Sclerosis -- Focal Lesions -- Guillain-Barré Syndrome -- Historical Background -- Clinical and Laboratory Features -- Diagnostic Criteria -- Antecedent Events -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Summary of Demyelinating Diseases -- NON-DEMYELINATING DISEASE -- Encephalopathy -- Subacute Sclerosing Panencephalitis -- Clinical and Laboratory Features -- Pathology and Pathogenesis -- Descriptive Epidemiology -- Residual Seizure Disorder -- Sensorineural Deafness -- Neuropathy -- Mononeuropathy -- Brachial Neuritis -- REFERENCES -- 4 Immunologic Reactions -- ANAPHYLAXIS -- INTERACTION OF ANTIBODY WITH NORMAL TISSUE ANTIGENS -- ARTHUS REACTION -- DELAYED-TYPE HYPERSENSITIVITY -- EFFECT OF VACCINES ON THE IMMUNE SYSTEM -- REFERENCES -- 5 Diphtheria and Tetanus Toxoids -- BACKGROUND AND HISTORY -- Tetanus -- Diphtheria -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Tetanus -- Diphtheria -- ENCEPHALOPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility.

Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series. and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- NEUROPATHY -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ARTHRITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ERYTHEMA MULTIFORME -- Clinical Description -- History of Suspected Association.

Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 6 Measles and Mumps Vaccines -- BACKGROUND AND HISTORY -- Measles -- Mumps -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- Measles -- Mumps -- ENCEPHALOPATHY AND ENCEPHALITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- ASEPTIC MENINGITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SUBACUTE SCLEROSING PANENCEPHALITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- RESIDUAL SEIZURE DISORDER -- Clinical Description -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies.

Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- SENSORINEURAL DEAFNESS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- OPTIC NEURITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Studies, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- INSULIN-DEPENDENT DIABETES MELLITUS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- STERILITY DUE TO ORCHITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies.

Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- THROMBOCYTOPENIA -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- ANAPHYLAXIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- DEATH -- Causality Argument -- Conclusion -- REFERENCES -- 7 Polio Vaccines -- BACKGROUND AND HISTORY -- BIOLOGIC EVENTS FOLLOWING IMMUNIZATION -- POLIOMYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors -- TRANSVERSE MYELITIS -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- GUILLAIN-BARRÉ SYNDROME -- Clinical Description -- History of Suspected Association -- Evidence for Association -- Biologic Plausibility -- Case Reports, Case Series, and Uncontrolled Observational Studies -- Controlled Observational Studies -- Controlled Clinical Trials -- Causality Argument -- Conclusion -- Risk-Modifying Factors.

ANAPHYLAXIS AND THROMBOCYTOPENIA.