Adverse Reproductive Outcomes in Families of Atomic Veterans: The Feasibility of Epidemiologic Studies -- Copyright -- Preface -- Contents -- Executive Summary -- CONCLUSIONS -- ORGANIZATION AND FRAMEWORK OF THE REPORT -- ADVERSE REPRODUCTIVE OUTCOMES -- ESTIMATION OF GENETIC RISK -- FEASIBILITY OF AN EPIDEMIOLOGIC STUDY -- Question 1. Definition of the Study Sample -- Question 2. Sample Size -- Question 3. Dose -- Question 4. Identification of Adverse Reproductive Outcomes -- ALTERNATIVE APPROACHES -- 1 Introduction -- AIMS OF THIS REPORT -- 2 Basic Epidemiologic Issues -- 3 Feasibility and Design of an Epidemiologic Study -- STUDY COHORT -- MEASUREMENT OF EXPOSURE -- DEFINING THE DISEASE AND ASCERTAINING THE CASES -- 4 Basic Principles of Radiation Biology -- BIOLOGICAL EFFECTS -- SOURCES OF RADIATION EXPOSURE -- POTENTIALLY SENSITIVE SUBGROUPS -- 5 Genetic Principles and Issues -- 6 Current Knowledge and Estimation of Genetic Risk -- BASIC ESTIMATION EQUATION -- DATA FROM WHICH RISK ESTIMATES HAVE BEEN MADE -- Mice -- Humans -- Estimating the Spontaneous Burden -- Estimating the Effect of Ionizing Radiation -- ESTIMATING THE DOUBLING DOSE -- Mice -- Humans -- 7 Adverse Reproductive Outcomes -- GENERAL REMARKS -- MALE-MEDIATED REPRODUCTIVE AND DEVELOPMENTAL OUTCOMES -- INFERTILITY -- Radionuclide Irradiation -- SPONTANEOUS ABORTIONS -- PRETERM DELIVERY -- STILLBIRTHS AND NEONATAL DEATHS (PERINATAL DEATHS) -- BIRTH DEFECTS -- Human Chromosome Abnormalities -- Developmental Abnormalities -- MATERNAL ILLNESSES -- ALTERED SEX RATIO -- MORTALITY AMONG THE CHILDREN OF EXPOSED PARENTS -- CANCER AND LEUKEMIA IN PARTICULAR -- IMMUNE DEFICIENCY -- NEUROLOGIC DEFICIT, INCLUDING MENTAL RETARDATION -- 8 Feasibility of the Study of Adverse Reproductive Outcomes in the Families of Veterans Exposed Ionizing Radiation.

DEFINITION OF A SUITABLE SAMPLE OR COHORT -- SIZE OF THE SAMPLE OR COHORT REQUIRED -- Question 1 -- Question 2 -- DOSIMETRY OF ATOMIC VETERANS -- IDENTIFICATION OF ADVERSE REPRODUCTIVE OUTCOMES -- 9 Alternative Approaches -- 10 Conclusions -- Glossary -- References.