Extending Life, Enhancing Life -- Copyright -- Preface -- Contents -- Executive Summary and Recommendations for Funding -- BACKGROUND -- Support for Training and Research in Geriatrics and Gerontology -- The Aging Society: Current Costs for Health Care of Older Persons -- The Potential of Research on Aging -- A NATIONAL RESEARCH AGENDA ON AGING -- Basic Biomedical Research -- Priority Research Recommendations -- Additional Research Opportunities -- Resource Recommendations -- Clinical Research -- Priority Research Recommendations -- Additional Research Opportunities -- Resource Recommendations -- Behavioral and Social Research -- Priority Research Recommendations -- Additional Research Opportunities -- Resource Recommendations -- Health Services Delivery Research -- Priority Research Recommendations -- Additional Research Opportunities -- Resource Recommendations -- Research in Biomedical Ethics -- Priority Research Recommendations -- Additional Research Opportunities -- Resource Recommendations -- CROSSCUTTING ISSUES -- Basic Biomedical Research -- Clinical Research -- Behavioral and Social Research -- Health Services Delivery Research -- RECOMMENDATIONS FOR FUNDING THE RESEARCH AGENDA ON AGING -- Derivation of Recommendations for Funding -- Funds for Research Projects -- Funds for Training in Age-Related Studies -- Funds for Centers -- Funds for Infrastructure -- Funds for Construction -- IMPLICATIONS FOR FUNDING AGENCIES -- CONCLUDING COMMENTS -- REFERENCES -- 1 Introduction -- 2 Basic Biomedical Research -- RESEARCH PRIORITIES -- ADDITIONAL RESEARCH OPPORTUNITIES -- RESOURCE RECOMMENDATIONS -- Funding of Research Proposals -- Materials -- Animal Models -- Cell Line and Tissue Samples -- Further Development of Existing Longitudinal Studies -- CROSSCUTTING ISSUES -- REFERENCES -- 3 Clinical Research -- RESEARCH PRIORITIES.

Health Promotion and Disease Prevention in Old Age -- Studies of Geriatric Syndromes -- Failure to Thrive (Inanition) -- Impaired Postural Stability, Strength, and Mobility -- Mismanagement of Medications -- Urinary Incontinence -- Delirium -- Cardiovascular Disease -- Dementia, Pseudodementia, and Psychiatric Disorders -- Musculoskeletal Disorders -- Infectious Disease and Immunosenescence -- Neoplasia -- Disorders of Metabolism and Homeostasis -- ADDITIONAL RESEARCH OPPORTUNITIES -- RESOURCE RECOMMENDATIONS -- CROSSCUTTING ISSUES -- REFERENCES -- 4 Behavioral and Social Sciences -- JUSTIFICATION AND MAJOR THEMES -- The Dynamic Interaction of Individuals and Sociocultural Contexts -- Differentiation -- Modifiability -- RESEARCH PRIORITIES -- ADDITIONAL RESEARCH OPPORTUNITIES -- METHODOLOGICAL NEEDS -- Tests and Instruments -- Coordination of Large-Scale Research -- Field Intervention Studies -- RESOURCE RECOMMENDATIONS -- CROSS-DISCIPLINARY AND CROSSCUTTING ISSUES -- Gender -- Race and Ethnicity, Socioeconomic Status, and Other Cultural Factors -- Population Dynamics -- Brain, Environment, Society, and Behavior -- REFERENCES -- 5 Health Services Delivery Research -- LONG-TERM CARE AND CONTINUITY OF CARE FOR OLDER PERSONS -- Characteristics of Older Persons Requiring Long-Term Care -- Informal Providers of Long-Term Care -- Formal Long-Term Care -- Supply of Personnel for Long-Term Care -- Locus of Long-Term Care -- Quality Assurance -- Technologies -- FINANCING OF HEALTH CARE FOR OLDER PERSONS -- DRUG USE -- Inappropriate Prescribing -- Noncompliance -- Drug Costs and Older Persons -- MENTAL HEALTH SERVICES -- DISABILITY/DISEASE PREVENTION AND HEALTH PROMOTION SERVICES -- RESEARCH PRIORITIES -- ADDITIONAL RESEARCH OPPORTUNITIES -- RESOURCES REQUIRED -- CROSS-DISCIPLINARY AND CROSSCUTTING ISSUES -- REFERENCES -- 6 Research in Biomedical Ethics.

RESEARCH PRIORITIES -- Life-Sustaining Treatment in Older Persons -- Improving Discussions About Life-Sustaining Treatment -- Improving Decision Making for Incompetent Patients Who Have Not Given Clear Advance Directives -- Defining the Role of Institutional Ethics Committees, Particularly Within Nursing Homes -- Establishing Medical Futility -- Resolving Disagreements Between Health Care Professionals and Patients (or Patients' Families) -- Issues of Equity and Access -- Identification of Criteria for Appropriate Practice Standards -- Age as a Criterion for Allocating Health Care Resources -- Allocation of Resources for Patient Care and for Research -- Ethical Issues in Aging Research -- Innovative Approaches to Informed Consent -- Proxy Consent for Incompetent Patients -- Attitudes Toward Participation in Research -- Research Review in Long-Term Care -- ADDITIONAL RESEARCH OPPORTUNITIES -- CONCLUSIONS AND RESOURCE RECOMMENDATIONS -- REFERENCES -- 7 Review of Resources Committed to Research on Aging -- FUNDING SUPPORT FOR RESEARCH ON AGING -- The Federal Government -- National Institutes of Health -- Department of Veterans Affairs -- Alcohol, Drug Abuse, and Mental Health Administration -- Health Care Financing Administration -- Agency for Health Care Policy and Research -- Other Federal Departments and Agencies -- Industry and Foundations -- Industry -- Foundations -- INSTITUTIONS ENGAGED IN RESEARCH ON AGING -- Centers for Research on Aging Supported by the NIA -- Centers for the Study of Alzheimer's Disease -- Centers of Excellence in Research and Teaching in Geriatrics and Gerontology (Claude Pepper Centers) -- Geriatric Research, Education, and Clinical Centers of the Department of Veterans Affairs -- Teaching and Research Nursing Homes -- Other Institutional Supports for the Study of Aging -- PUBLICATIONS ON RESEARCH IN AGING.

PERSONNEL ENGAGED IN THE STUDY OF AGING -- REFERENCES -- Appendixes -- A Acknowledgments -- Liaison Teams -- Basic Biomedical Research -- Clinical Research -- Behavioral and Social Sciences -- Behavioral Sciences -- Social Sciences -- Health Services Delivery Research -- Biomedical Ethics -- Experts Providing Information to the Committee -- Directors, Dva Geriatric Research, Education, and Clinical Centers -- Directors, Pharmaceutical Company Research -- B Background Documents -- Index.