ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER -- Copyright -- Statement of Purpose -- Contents -- ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER -- 1 Introduction -- OUTLINE OF MOLECULAR GENETICS -- BRIEF OVERVIEW OF CANCER GENETICS -- 2 Testing for Tumor-Specific Genetic Markers -- MICROSCOPIC DETECTION OF ALTERATIONS IN DNA STRUCTURE -- In Situ Hybridization -- Ploidy Analysis -- TECHNIQUES FOR DETECTING CHANGES IN DNA STRUCTURE AT THE SUBMICROSCOPIC LEVEL -- Southern Blot Hybridization -- Pulsed-Field Gel Electrophoresis -- Polymerase Chain Reaction -- TECHNIQUES FOR DETECTION OF POINT MUTATIONS IN DNA -- TECHNIQUES DIRECTED AT ANALYSIS OF RNA -- TECHNIQUES FOR ANALYZING CHANGES AT THE PROTEIN LEVEL -- Immunohistochemistry -- 3 Hematologic Cancer -- CHRONIC MYELOGENOUS LEUKEMIA -- CHRONIC LYMPHOCYTIC LEUKEMIA -- ACUTE LYMPHOCYTIC LEUKEMIA -- ACUTE MYELOGENOUS LEUKEMIA -- MYELODYSPLASTIC SYNDROMES -- LYMPHOMA -- 4 Solid Tumors -- CHROMOSOMAL ABERRATIONS OF DIAGNOSTIC IMPORTANCE -- CHROMOSOMAL ABERRATIONS OF PROGNOSTIC IMPORTANCE -- Neuroblastoma -- Breast Cancer -- Lung Cancer -- Other Solid Tumors -- GENETIC MARKERS OF PREDISPOSITION TO CANCER -- Retinoblastoma -- Mapping of Other Cancer Predisposition Loci -- Li-Fraumeni Syndrome -- Loss of Heterozygosity in Sporadic Solid Tumors -- GENETIC CHANGES AND TUMOR PROGRESSION -- Colorectal Neoplasms -- Glial Tumors -- CANCER-ASSOCIATED GENETIC CHANGES AND ENVIRONMENTAL MUTAGENS -- VIRAL MARKERS IN CANCER DIAGNOSIS -- 5 Summary and Specific Recommendations -- PRACTICAL ASPECTS OF GENETIC ANALYSIS: FROM PATIENT TO DIAGNOSTIC LABORATORY -- THE MOLECULAR DIAGNOSTIC LABORATORY -- IMPLICATIONS OF COMMERCIALIZATION -- FUTURE NEEDS -- 6 References.