IMMUNIZATION SAFETY REVIEW -- Copyright -- Acknowledgments -- Contents -- Executive Summary -- ABSTRACT -- DEMYELINATING NEUROLOGICAL DISORDERS -- HEPATITIS B VIRAL INFECTION -- HEPATITIS B VACCINE -- EVIDENCE REVIEWED BY THE COMMITTEE -- CAUSALITY ASSESSMENT -- BIOLOGICAL MECHANISMS ASSESSMENT -- SIGNIFICANCE ASSESSMENT -- RECOMMENDATIONS FOR PUBLIC HEALTH RESPONSE -- Policy Review -- Research -- Surveillance -- Basic and Clinical Science -- Communication -- REFERENCES -- Immunization Safety Review: Hepatitis B Vaccine and Demyelinating Neurological Disorders -- THE CHARGE TO THE COMMITTEE -- THE STUDY PROCESS -- THE FRAMEWORK FOR SCIENTIFIC ASSESSMENT -- Causality -- Biological Mechanisms -- Terminology -- Categories of Evidence -- Published and Unpublished Data -- UNDER REVIEW: HEPATITIS B VACCINE AND DEMYELINATING NEUROLOGICAL DISORDERS -- Adverse Neurological Events -- Multiple Sclerosis -- Acute Disseminated Encephalomyelitis -- Optic Neuritis -- Transverse Myelitis -- Guillain-Barré Syndrome -- Peripheral Neuritis -- Hepatitis B Virus Infection and Hepatitis B Vaccines -- SCIENTIFIC ASSESSMENT -- Causality -- Case Reports -- Multiple Sclerosis -- Causality Argument -- First Episode of a Central Nervous System Demyelinating Disorder -- Acute Disseminated Encephalomyelitis -- Optic Neuritis -- Transverse Myelitis -- Brachial Neuritis -- Biological Mechanisms -- Immune-Mediated Processes in MS and Other Demyelinating White-Matter Diseases -- Theoretical Mechanisms for Infection-Induced Immune-Mediated Injury -- Theoretical Mechanisms for Vaccine-Induced Demyelinating Diseases -- Evidence from Animal Models for a Possible Role for Hepatitis B Vaccine in Demyelination -- Evidence from Humans -- Known Effects of Other Vaccines -- Conclusions Regarding Biological Mechanisms -- SIGNIFICANCE ASSESSMENT.

Disease Burden Associated with Multiple Sclerosis -- Hepatitis B Vaccine Safety Concerns in France -- Hepatitis B Virus Infection -- Prevention Strategies -- Acceptance of the Hepatitis B Vaccine in the United States -- Information on the Safety of the Hepatitis B Vaccine -- Conclusions -- RECOMMENDATIONS FOR PUBLIC HEALTH RESPONSE -- Policy Review -- Research -- Surveillance -- Basic and Clinical Science -- Communication -- SUMMARY -- REFERENCES -- Appendix A Committee Conclusions and Recommendations from Previous Reports -- MEASLES-MUMPS-RUBELLA VACCINE AND AUTISM -- Conclusions -- Recommendations -- Public Health Response -- Policy Review -- Research Regarding MMR and ASD -- Communications -- THIMEROSAL-CONTAINING VACCINES AND NEURODEVELOPMENTAL DISORDERS -- Conclusions -- Public Health Response Recommendations -- Policy Review and Analysis -- Public Health and Biomedical Research -- Epidemiological Research -- Clinical Research -- Basic Science Research -- MULTIPLE IMMUNIZATIONS AND IMMUNE DYSFUNCTION -- Conclusions -- Scientific Assessment -- Causality Conclusions -- Biological Mechanisms Conclusions -- Significance Assessment -- Public Health Response Recommendations -- Policy Review -- Research -- Epidemiological Research -- Basic Science and Clinical Research -- Communication -- Appendix B Public Meeting Agenda March 11, 2002 -- Appendix C Chronology of Important Events Regarding Vaccine Safety.