Comparative Dosimetry of Radon in Mines and Homes -- Copyright -- Preface -- CHARGE TO THE COMMITTEE -- ORGANIZATION OF THE STUDY -- ORGANIZATION OF THE REPORT -- ACKNOWLEDGMENTS -- Contents -- Summary and Recommendations -- RECOMMENDATIONS FOR FURTHER RESEARCH AND ANALYSIS -- REFERENCES -- 1 Introduction -- CONCENTRATION, EXPOSURE, AND DOSE -- RISK ASSESSMENT FOR INDOOR RADON -- SUMMARY -- REFERENCES -- 2 Assessment of Exposure to the Decay Products of 222Rn in Mines and Homes -- INTRODUCTION -- BACKGROUND -- MEASUREMENT METHODS -- EXPOSURE TO RADON PROGENY -- Mine Atmospheres -- Indoor Atmospheres -- REFERENCES -- 3 Extrapolation of Doses and Risk per Unit Exposure from Mines to Homes -- INTRODUCTION -- REPRESENTATIVE EXPOSURE CONDITIONS -- Radon Progeny Aerosols -- BREATHING RATES AND CALCULATION OF DOSE PER UNIT EXPOSURE -- COMPARATIVE DOSES FROM RADON PROGENY IN MINES AND HOMES -- Target Cells in Bronchial Epithelium -- LOCALIZED VERSUS REGIONAL DOSES -- INFLUENCE OF MODELING UNCERTAINTIES -- DOSES TO ADULT FEMALES -- DOSES TO CHILDREN AND INFANTS -- VARIABILITY OF THE DOSE CONVERSION COEFFICIENT IN HOMES -- EFFECTS OF AIRWAY DISEASE ON DOSE -- COMPARATIVE DOSES FROM RADON AND THORON PROGENY -- SUMMARY OF DOSIMETRIC RISK EXTRAPOLATION FACTORS -- REFERENCES -- 4 Other Considerations -- BIOLOGICAL FACTORS -- GENDER -- AGE, GROWTH, AND INJURY IN RELATION TO CELL PROLIFERATION -- AGE -- CELL PROLIFERATION -- DOSE RATE, FRACTIONATION, AND DURATION OF EXPOSURE -- TISSUE DAMAGE -- CIGARETTE SMOKING -- REFERENCES -- 5 Dosimetry and Dosimetric Models for Inhaled Radon and Progeny -- SOME PHYSICAL CHARACTERISTICS OF RADON AND RADON PROGENY -- MORPHOMETRIC MODELS OF THE RESPIRATORY TRACT -- HEAD AIRWAY MORPHOMETRY -- TRACHEOBRONCHIAL AIRWAY MORPHOMETRY -- RESPIRATORY AIRWAY MORPHOMETRY -- DEPOSITION MODELS OF THE RESPIRATORY TRACT.

CLEARANCE MODELS OF THE RESPIRATORY TRACT -- DOSIMETRY MODELS OF THE RESPIRATORY TRACT -- REFERENCES -- 6 Aerosols in Homes and Mines -- RELATIONSHIP BETWEEN PARTICLE SIZE AND DIFFUSION COEFFICIENT -- Penetration of Aerosols Through a Tube -- Deposition of Ultrafine Particles onto Wire Screens -- MEASUREMENT METHODS FOR UNATTACHED FRACTION -- Diffusion Sampler -- Wire Screen Samplers -- REVIEW OF PAST UNATTACHED FRACTION MEASUREMENTS IN MINE ATMOSPHERES -- Diffusion Sampler Measurements -- Wire Screen Measurements -- Summary of Mining Exposure -- INDOOR ATMOSPHERES -- Diffusion Sampler Measurements -- Wire Screen Measurements -- ACTIVITY-WEIGHTED SIZE DISTRIBUTIONS -- Summary of Indoor Exposure -- REFERENCES -- 7 Breathing, Deposition, and Clearance -- INTRODUCTION -- DEPOSITION OF RADON PROGENY: GENERAL PRINCIPLES -- FACTORS ACTING TO DEPOSIT PARTICLES IN THE LUNGS -- Diffusional -- Gravitational -- Inertia -- Other Forces -- Aerosol Characteristics -- Breathing Pattern -- Anatomy of the Respiratory System -- CLEARANCE OF RADON PROGENY: GENERAL PRINCIPLES -- Mucociliary Transport -- Nonciliated Regions -- Cough -- DIFFERENCES BETWEEN WORKERS AND THE PUBLIC -- Anatomic Variations -- Breathing Pattern -- Activity Level and Exercise -- Oral Versus Nasal Breathing -- OTHER MODIFYING FACTORS INFLUENCING DEPOSITION AND/OR CLEARANCE OF RADON PROGENY -- Preexisting Disease -- Smoking -- OTHER CHARACTERISTICS OF WORKERS AND THE PUBLIC -- Occupancy Data -- Ethnic Differences -- Altitude -- Species Differences -- CONCLUSIONS -- REFERENCES -- 8 Cells of Origin for Lung Cancer -- OVERVIEW -- STRUCTURE OF THE LUNG -- PATHOLOGY OF LUNG CANCER -- BASIC CONCEPTS OF LUNG CANCER DEVELOPMENT -- Multistep Process of Lung Cancer Development -- Genetic and Chromosomal Alterations in Lung Cancer -- CELLS FROM WHICH LUNG CANCERS DEVELOP.

TYPES AND INCIDENCE OF LUNG CANCER IN URANIUM MINERS -- DISCUSSION -- REFERENCES -- 9 The Committee's Dosimetric Model for Radon and Thoron Progeny -- INTRODUCTION -- DOSIMETRIC ASSUMPTIONS AND MODEL -- CLEARANCE MODEL -- DEPOSITION MODEL -- NASAL AND ORAL FILTRATION -- Definition of Exposure and Reference Breathing Rates -- Contributions of Individual Radon Progeny to the WLM -- Contributions of Individual Thoron Progeny to the WLM -- Reference Breathing Rates -- Exposure-Dose Conversion Coefficients -- Influence of Aerosol Size, Clearance Behavior, and Target Cells -- Influence of Exercise -- Influence of Age and Gender -- Influence of Airway Disease -- REFERENCES -- Index.