Multiple Chemical Sensitivities -- Copyright -- Contents -- Introduction -- REFERENCES -- OVERVIEW -- Research Protocol for Clinical Evaluation -- WORKING GROUP I -- CASE CRITERIA -- CANDIDATE POPULATIONS -- EVALUATION -- Exposures and Mechanisms -- WORKING GROUP II -- HUMAN STUDIES -- OTHER EXPERIMENTAL APPROACHES -- ADDITIONAL NEEDS -- Epidemiology -- WORKING GROUP III -- Key Concepts: Chemical Sensitization -- INTRODUCTION -- MECHANISMS OF SENSITIZATION -- Classic Sensitization -- Inflammation -- Other Mechanisms of Sensitization -- Different Pathways -- Irritant Mechanisms -- FORMALDEHYDE -- Potential Mechanisms of Formaldehyde Induced Respiratory Sensitivity -- Evidence of Asthma in Humans -- Skin Sensitization -- Current Levels of Knowledge -- REFERENCES -- Multiple Chemical Sensitivity-What is It? -- REFERENCES -- Case Definitions for Multiple Chemical Sensitivity -- TERMINOLOGY -- REFERENCES -- Allergy and Multiple Chemical Sensitivities Distinguished -- SUMMARY OF ADAPTATION HYPOTHESES -- REFERENCES -- Design of Animal Models to Probe the Mechanisms of Multiple Chemical Sensitivity -- INTRODUCTION -- ANIMAL MODELS OF ENVIRONMENTAL LUNG DISEASES -- Monitoring of Responses -- EVALUATION OF ANIMAL MODELS -- Respiratory Hypersensitivity -- Guinea Pig Model of Airway Hyperreactivity -- ANIMAL MODEL FOR ORGANIC DUST TOXIC SYNDROME -- AN ANIMAL MODEL OF MCS -- SUMMARY -- ACKNOWLEDGEMENT -- REFERENCES -- Antigen Specific and Antigen Non-Specific Immunization -- REFERENCES -- Neuropsychiatric & Biopsychosocial Mechanisms in Multiple Chemical Sensitivity: An Olfactory-Limbic System Model -- INTRODUCTION -- CONTROLLED STUDIES ON MULTIPLE CHEMICAL SENSITIVITY PATIENTS -- OLFACTORY-LIMBIC SYSTEM MODEL AND AFFECTIVE SPECTRUM DISORDERS -- Affective Spectrum Disorders -- Olfactory Bulbectomy Model of Depression.

Anxiety Disorders and Environmental Chemicals -- Kindling and Long-Term Potentiation in the Limbic System: Possible Role in the Mechanisms of MCS -- Brain Electrical Activity and Chemical Exposures -- PSYCHOSOCIAL MODULATORS OF BIOLOGICAL EVENTS -- Possible Mediators in MCS -- Classical Conditioning Hypothesis -- METHODOLOGICAL ISSUES -- CONCLUSIONS -- REFERENCES -- Neurobehavioral and Psychosocial Aspects of Multiple Chemical Sensitivity -- CHARACTERISTICS OF MCS PATIENTS -- PSYCHOSOCIAL AND PSYCHIATRIC EVALUATION -- RESULTS AND CONCLUSION -- CONCLUSION -- REFERENCES -- Acknowledgments -- Diagnostic Markers of Multiple Chemical Sensitivity -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- CONCLUSIONS -- REFERENCES -- Possible Mechanisms for Multiple Chemical Sensitivity: The Limbic System and Others -- MECHANISMS INVOLVING THE LIMBIC SYSTEM -- BIOCHEMICAL MECHANISMS -- VASCULAR MECHANISMS -- REFERENCES -- Developing Clinical Research Protocols for Studying Chemical Sensitivities -- Immunological Mechanisms of Disease and the Multiple Chemical Sensitivity Syndrome -- INTRODUCTION -- DESCRIPTIONS OF THE MULTIPLE CHEMICAL SENSITIVITY SYNDROME -- IMMUNOPATHOGENESIS OF DISEASE AND CHEMICAL SENSITIVITIES -- REVIEW OF SELECTED PUBLISHED DATA ON IMMUNE ABNORMALITIES IN CHEMICALLY SENSITIVE PATIENTS -- NEUROIMMUNOLOGY AND CHEMICAL SENSITIVITIES -- SUMMARY -- REFERENCES -- Considerations for the Diagnosis of Chemical Sensitivity -- INTRODUCTION -- DEFINITION AND PRINCIPLES -- TOTAL BODY LOAD (BURDEN) -- ADAPTATION (MASKING, ACUTE TOXICOLOGICAL TOLERANCE) -- BIPOLARITY -- BIOCHEMICAL INDIVIDUALITY -- SPREADING PHENOMENA -- SWITCH PHENOMENON -- POLLUTION FACTS -- WATER POLLUTION -- CHEMICAL CONTAMINATION IN FOODS -- CHEMICAL INCITANTS IN THE HOME ENVIRONMENT -- MECHANISMS -- IMMUNOLOGICAL -- NON-IMMUNE ENZYME DETOXIFICATION -- DIAGNOSIS.

TREATMENT -- CONCLUSION -- REFERENCES -- Occupational Asthma -- REFERENCES -- Workshop to Develop Research Protocols for Multiple Chemical Sensitivity -- CONTRIBUTORS -- Workshop to Develop Research Protocols for Multiple Chemical Sensitivity -- PARTICIPANTS.