Technical Assessment of the Man-In-Simulant Test (MIST) Program -- Copyright -- Preface -- Contents -- Acronyms -- Executive Summary -- GENERAL CONCLUSIONS AND RECOMMENDATIONS -- 1 Introduction -- BACKGROUND -- CHARGE TO THE COMMITTEE -- STUDY APPROACH -- 2 Test Protocol -- UNDERLYING CONCEPTS -- Introduction -- Materials Evaluation -- Suit Technology -- Evaluation of Suit Systems -- METHODOLOGY -- Methods for Evaluating Protective Clothing -- MIST Test Procedure -- Body Region Hazard Analysis -- Evaluation of Suits against Exposure to HD (Local Analysis) -- Evaluation of Suits against Exposure to VX (Systemic Analysis) -- 3 Simulant Section -- IMPORTANCE OF DERMAL PENETRATION -- USE OF SIMULANT TO PREDICT DERMAL PENETRATION -- SELECTION OF A SIMULANT -- TOXICITY OF METHYL SALICYLATE -- FINAL CHOICE OF A SIMULANT FOR MIST -- 4 Test Methods and Sampler Selection -- PURPOSES OF MONITORING -- RATIONALE FOR THE SELECTION OF MONITORING METHODS -- CHAMBER MONITORING -- OPTIONS FOR IN-SUIT MONITORING -- Active Sampling Systems -- Overview -- External Pumps and Tubes -- Pumps and Sampling Systems inside the Protective Garment -- Passive Samplers -- Natick Sampler -- 5 Assumptions and Limitations -- TEST PROTOCOL CONSIDERATIONS -- HUMAN FACTORS CONSIDERATIONS -- ACETYLCHOLINESTERASE INHIBITION AS A BIOLOGICAL MARKER -- BIOLOGICAL INTERPRETATION OF THE MIST/BRHA -- 6 Conclusions and Recommendations -- SPECIFIC CONCLUSIONS AND RECOMMENDATIONS -- GENERAL CONCLUSIONS AND RECOMMENDATIONS -- References -- APPENDICES -- Appendix A Body Region Hazard Analysis -- INTRODUCTION -- CONCEPTS -- OPPORTUNITIES AND APPLICATIONS -- NOMENCLATURE -- REFERENCES -- Appendix B Panel and Committee Meetings -- PANEL MEETINGS -- Presenters -- Presenters -- FULL COMMITTEE MEETINGS -- Presenters -- Presenters.