Biomedical Models and Resources -- Copyright -- Preface -- Contents -- Executive Summary -- 1 Introduction -- THE COMMITTEE'S CHARGE AND APPROACH -- STRUCTURE OF THE REPORT -- 2 Biomedical Model Definition -- 3 Essential and Emerging Research Fields and Technologies -- FUNCTIONAL GENOMICS -- AGING -- BEHAVIOR AND NEUROBIOLOGY -- COMPLEX DISEASE -- MODEL DISCOVERY -- MATHEMATICAL MODELLING, COMPUTATIONAL SIMULATIONS, AND SCIENTIFIC DATABASES -- EMERGING AND RE-EMERGING INFECTIOUS DISEASES -- 4 Overriding Issues -- ISSUES WITHIN THE PURVIEW OF NCRR -- MAINTENANCE AND PRESERVATION -- FACILITY INFRASTRUCTURE -- AVAILABILITY OF EXPERTISE AND TRAINING -- INFECTIOUS DISEASE, ANIMAL HEALTH -- ISSUES BEYOND THE SCOPE OF NCRR -- CIRCULAR A-21 -- INTELLECTUAL PROPERTY RIGHTS -- DATABASES AND CONFIDENTIALITY -- 5 Recommendations -- ENCOURAGE AND SUPPORT RESEARCH DIRECTED AT IMPROVING RESEARCH ANIMALUTILITY, AVAILABILITY, HEALTH, WELFARE, AND MAINTENANCE -- LABORATORY ANIMAL HEALTH AND WELFARE -- Diagnosis and infectious disease -- Behavior -- IMPROVED ANIMAL ACQUISITION, MAINTENANCE, PROPAGATION AND PRESERVATION -- DEVELOPMENT OF GENETIC MAPS FOR ADDITIONAL MODEL SPECIES -- INSTRUMENTATION DEVELOPMENT AND MINIATURIZATION -- CREATE A NATIONAL NETWORK OF COMPARATIVE MEDICAL EXPERTISE -- TO SUPPORT NIH RESEARCH EFFORTS ON ANIMAL MODELS, SUCH AS PHENOTYPICAND GENOTYPIC ASSESSMENT AND DISEASE DIAGNOSTICS -- TO PROMOTE MULTIDISCIPLINARY INTERACTION -- CREATE A NATIONAL NETWORK OF INTEGRATIVE-BIOLOGY EXPERTISE THAT CANSERVE THE ENTIRE BIOMEDICAL RESEARCH COMMUNITY -- ACADEMIC INFRASTRUCTURE FOR INTEGRATIVE BIOLOGY RELATED TO ANIMALS -- MATHEMATICAL MODELLING, COMPUTATIONAL SIMULATIONS, AND SCIENTIFIC DATABASES -- Encouragement and Facilitation of Interdisciplinary Research -- Development and Dissemination of Appropriate Information Technologies.

Development and Maintenance of Databases, Interdisciplinary Modelling and Informatics Issues. The Si ... -- INCREASE THE COMMITMENT AND RESOURCES FOR CONSTRUCTING AND RENOVATINGANIMAL RESEARCH FACILITIES -- REINVIGORATE AND EXPAND TRAINING OPPORTUNITIES IN INTEGRATIVE BIOLOGY -- OBTAIN PROGRAM GUIDANCE FROM THE SCIENTIFIC COMMUNITY -- USE EXISTING MECHANISMS BETTER -- FUND INDEPENDENT EXTERNAL ADVISORY GROUPS EVERY FOUR YEARS -- 6 Criteria -- References -- APPENDIXES -- APPENDIX A SURVEY INSTRUMENT -- Future Trends in Biomedical Research -- BIOMEDICAL MODELS FOR THE NEXT 5-10 YEARS -- CURRENT MODELS WAITING TO BE DEVELOPED -- IDENTIFYING NEW BIOLOGICAL MODELS -- APPENDIX B BIOGRAPHICAL SKETCHES OF AUTHORING COMMITTEE -- WORKSHOPAGENDA -- AND WORKSHOP PARTICIPANTS -- APPENDIX C Models for Biomedical Research -- What Is a Model? -- REFERENCES -- APPENDIX D COMPARATIVE MEDICAL SCIENTISTS' REPORT -- A. Biotechnology -- B. Specialized Facilities -- C. Diagnostics -- D. Informatics -- E. Training -- F. Administration -- G. Personnel -- H. Facilities.