Research Priorities for Airborne Particulate Matter -- Copyright -- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- Preface -- Contents -- Executive Summary -- THE COMMITTEE'S 1998 AND 1999 REPORTS -- THE PARTICULATE-MATTER RESEARCH PROGRAM -- REVIEW OF PROGRESS AND STATUS OF RESEARCH -- Research Topic 1. Outdoor Measures Versus Actual Human Exposures -- Research Topic 2. Exposures of Susceptible Subpopulations to Toxic Particulate-Matter Components -- Research Topic 3. Characterization of Emission Sources -- Research Topic 4. Air-Quality Model Development and Testing -- Research Topic 5. Assessment of Hazardous Particulate-Matter Components -- Research Topic 6. Dosimetry: Deposition and Fate of Particles in the Respiratory Tract -- Research Topic 7. Combined Effects of Particulate Matter and Gaseous Pollutants -- Research Topic 8. Susceptible Subpopulations -- Research Topic 9. Mechanisms of Injury -- Research Topic 10. Analysis and Measurement -- OVERARCHING ISSUES RELATED TO IMPLEMENTATION OF THE PARTICULATE-MATTER RESEARCH PROGRAM -- Disincentives and Incentives for Multidisciplinary Interaction Among Particulate-Matter Researchers -- Integration and Planning Particulate-Matter Research Across Federal Agencies -- Connecting Research Management to Standard Implementation -- Accessibility of Information -- Overall Evaluation of Particulate-Matter Research Progress -- What Is Success? -- 1 The Committee's Task and the Particulate-Matter Research Enterprise -- THE COMMITTEE'S TASK -- THE PARTICULATE-MATTER RESEARCH PROGRAM -- Research Centers -- Ambient-Air Monitoring -- Particulate-Matter Management Infrastructure -- ORGANIZATION OF THIS REPORT -- 2 Evaluating Implementation and Progress of Research -- APPLYING THE COMMITTEE'S RESEARCH CRITERIA -- Research-Outcome Criteria -- Scientific Value -- Decisionmaking Value.

Feasibility and Timing -- Research-Planning Criteria -- Multidisciplinary Interaction -- Integration and Planning -- Accessibility of Information -- Considerations in Applying the Criteria -- SOURCES OF INFORMATION -- 3 Review of Research Progress and Status -- INTRODUCTION -- RESEARCH TOPIC 1. OUTDOOR MEASURES VERSUS ACTUAL HUMAN EXPOSURES -- Research Progress and Status -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 2. EXPOSURES OF SUSCEPTIBLE SUBPOPULATIONS TO TOXIC PARTICULATE-MATTER COMPONENTS -- RESEARCH TOPIC 3. CHARACTERIZATION OF EMISSION SOURCES -- Research Progress and Status -- Establish Standard Source-Test Methods for Measurement of Particle Size and Chemical Composition -- Characterize Primary Particle Size and Composition of Emissions -- Develop New Measurement Methods and Use of Data to Characterize Sources of Gas-Phase Ammonia and Semivolatile Organic Vapors -- Translate New Source-Test Procedures and Source-Test Data into Comprehensive National Emission Inventories -- Application of Evaluation Criteria Scientific Value -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 4. AIR-QUALITY MODEL DEVELOPMENT AND TESTING -- Air-Quality Model Development -- Source-Oriented Models -- Receptor-Oriented Models -- Air-Quality Model Testing -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- Integration and Planning -- RESEARCH TOPIC 5. ASSESSMENT OF HAZARDOUS PARTICULATE-MATTER COMPONENTS -- Research Progress and Status -- Toxicology -- Epidemiology -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value.

Feasibility and Timing -- RESEARCH TOPIC 6. DOSIMETRY: DEPOSITION AND FATE OF PARTICLES IN THE RESPIRATORY TRACT -- Deposition -- Translocation, Clearance, and Bioavailability -- Adequacy of Current Research in Addressing Information Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 7. COMBINED EFFECTS OF PARTICULATE MATTER AND GASEOUS POLLUTANTS -- Research Progress and Status -- Toxicology -- Epidemiology -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 8. SUSCEPTIBLE SUBPOPULATIONS -- Research Progress and Status -- Controlled-Exposure Studies -- Epidemiology -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 9. MECHANISMS OF INJURY -- Research Topic 9a. Animal Models -- Research Progress and Status -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- Research Topic 9b. In Vitro Studies -- Research Progress and Status -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- Research Topic 9c. Clinical Models -- Research Progress and Status -- Adequacy of Current Research in Addressing Research Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- RESEARCH TOPIC 10. ANALYSIS AND MEASUREMENT -- General Methodological Issues -- Model Development and Evaluation -- Measurement Error -- Harvesting.

Spatial Analytical Methods -- Adequacy of Current Research in Addressing Information Needs -- Application of Evaluation Criteria -- Scientific Value -- Decisionmaking Value -- Feasibility and Timing -- 4 Overall Findings and Recommendations -- KEY FINDINGS AND RECOMMENDATIONS CONCERNING SCIENTIFIC VALUE, DECISIONMAKING VALUE, AND TIMING AND FEASIBILITY OF… -- Exposure Assessment -- Characterization of Emission Sources -- Air-Quality Model Development and Testing -- Dosimetry -- Toxicology -- Epidemiology -- Susceptible Subpopulations -- Analysis and Measurement -- IMPLEMENTATION OF SUPERSITE AND SPECIATION PROGRAMS: A CASE STUDY -- OVERARCHING ISSUES RELATED TO IMPLEMENTATION OF PARTICULATE-MATTER RESEARCH PROGRAM -- Disincentives and Incentives for Multidisciplinary Interaction Among Particulate-Matter Researchers -- Integration and Planning of Particulate-Matter Research Across Federal Agencies -- Connecting Research Management to Standard Implementation -- Accessibility of Information -- OVERALL EVALUATION OF PARTICULATE-MATTER RESEARCH PROGRESS -- WHAT IS SUCCESS? -- References -- Appendix A Biographical Information on the Committee on Research Priorities for Airborne Particulate Matter -- Appendix B The Committee's Statement of Task.