Use of Laboratory Animals in Biomedical and Behavioral Research -- Copyright -- Contents -- Preface -- Executive Summary -- PATTERNS OF ANIMAL USE -- BENEFITS DERIVED FROM THE USE OF ANIMALS -- ALTERNATIVE METHODS IN BIOMEDICAL AND BEHAVIORAL RESEARCH -- REGULATORY ISSUES -- USE OF POUND ANIMALS -- 1 Introduction -- HISTORICAL BACKGROUND -- Use of Animals in Research -- Concerns Over Animal Use -- PRESENT SITUATION -- 2 Patterns of Animal Use -- NUMBERS OF ANIMALS USED -- USE OF ANIMALS IN RESEARCH BY THE FEDERAL GOVERNMENT -- USE OF ANIMALS IN EDUCATION -- USE OF ANIMALS IN TESTING -- NEW TECHNOLOGIES AND FUTURE LABORATORY USE OF ANIMALS -- SUMMARY -- 3 Benefits Derived from the Use of Animals -- POLIO -- ACQUIRED IMMUNE DEFICIENCY SYNDROME -- TRANSPLANTATION -- CARDIOVASCULAR-RENAL SYSTEMS -- NERVOUS SYSTEM -- Movement and Function -- Behavior -- Postnatal Development of the Visual Cortex and the Influence of Environment -- Memory -- Pain -- OTHER BENEFITS FOR HUMANS -- BENEFITS FOR ANIMALS -- SUMMARY -- 4 Alternative Methods in Biomedical and Behavioral Research -- RELATIONSHIPS AMONG LIFE FORMS -- ANIMAL MODELS -- ALTERNATIVES TO MAMMALS -- Nonmammalian Vertebrates -- Invertebrates -- Microorganism -- Cell and Tissue Cultures -- Human Tissues -- In Vitro Systems and Mathematical Models -- Refinements -- ALTERNATIVE METHODS IN TESTING -- SUMMARY -- 5 Regulatory Issues -- APPROACHES TO REGULATION -- FEDERAL REGULATIONS -- Legislation Passed in 1985: The Health Research Extension Act and the Food Security Act -- GOVERNMENT POLICY STATEMENTS -- Guide for the Care and Use of Laboratory Animals -- Public Health Service Policy on Humane Care and Use of Laboratory Animals -- Good Laboratory Practices Regulations -- STATE REGULATIONS -- APPROACHES TO REGULATION -- Granting Agency Approach to Regulation -- Self-Regulation -- EFFECTS OF REGULATIONS.

Effects on Training and Education -- Effects on Experimental Results -- Effects on Direct Expense of Research -- Effects on the Animals -- ENFORCEMENT AND ENACTMENT OF REGULATIONS AND LAWS -- 6 Use of Pound Animals -- SUPPLY OF POUND ANIMALS -- REGULATIONS -- SCIENTIFIC CONSIDERATIONS -- BENEFITS -- COST CONSIDERATIONS -- CONCERNS FOR THE ANIMALS -- 7 Conclusions and Recommendations -- RECOMMENDATIONS -- References -- Individual Statements by Members of the Committee on the Use of Laboratory Animals in Biomedical and ... -- ARTHUR C. GUYTON -- CHRISTINE STEVENS -- Appendix A 1896 Report of the National Academy of Sciences -- Appendix B Curricula Vitae of Committee Members -- Appendix C Invited Speakers at Committee Meetings -- Index.