METHYL BROMIDE RISK CHARACTERIZATION IN CALIFORNIA -- Copyright -- Preface -- Contents -- Executive Summary -- THE SUBCOMMITTEE'S TASK -- THE SUBCOMMITTEE'S EVALUATION -- Toxicology -- Recommendations -- Exposure -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- BACKGROUND -- CALIFORNIA REGULATIONS -- THE SUBCOMMITTEE'S TASK -- ORGANIZATION OF THE REPORT -- 2 Toxicology and Hazard Identification -- PHARMACOKINETICS -- GENOTOXICITY -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- CHRONIC INHALATION AND ONCOGENICITY -- REPRODUCTIVE TOXICITY -- DEVELOPMENTAL TOXICITY -- NEUROTOXICITY -- SELECTION OF CRITICAL EFFECTS FOR ACUTE TOXICITY -- 3 Exposure Assessment -- BACKGROUND -- LIKELY EXPOSURE SCENARIOS -- QUALITY OF DATA AVAILABLE FOR CHARACTERIZING EXPOSURES -- Analytical Methods -- Representativeness of Available Exposure Measurements -- Appropriateness of Normalizing Assumptions for Different Application Rates -- Appropriateness of Exposure-Duration Assumptions -- ACCURACY AND APPROPRIATENESS OF AVAILABLE MODELING TOOLS -- Exposure Estimates Based on Modeling -- Exposure of Residents in a Fumigated House -- Exposure of Residents Downwind from Soil Fumigations -- SUMMARY -- 4 Risk Characterization -- RISK CHARACTERIZATION GOALS -- HAZARD IDENTIFICATION -- Acute Toxicity Database -- Subchronic Toxicity Database -- Chronic Toxicity Database -- Developmental Neurotoxicity -- EXPOSURE ASSESSMENT -- Appropriateness of Acute-Exposure Definition -- Subchronic Exposure -- Chronic Exposure -- MARGIN-OF-EXPOSURE ANALYSIS -- Categories with More than Two Data Points -- Categories with One or Two Data Points -- UNCERTAINTY ISSUES -- Derivation of Reference Concentrations -- Sensitive Subpopulations -- Multiple Exposures -- SUMMARY -- 5 Conclusions and Recommendations -- TOXICOLOGICAL INFORMATION -- Conclusions -- Recommendations.

EXPOSURE ASSESSMENT -- Conclusions -- Recommendations -- RISK CHARACTERIZATION -- Conclusions -- Recommendations -- References -- Appendix A Biographical Information on the Subcommittee for the Review of the Risk Assessment of Methyl Bromide -- Appendix B Public Access Materials -- Appendix C Calculation of Air Exchange Rates -- ILLUSTRATIVE LOGNORMAL TREATMENT OF DATA FOR SELECTED OCCUPATIONAL EXPOSURES.