Front Cover -- The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents -- Copyright Page -- Contents -- Preface -- List of Contributors -- List of Reviewers -- I. GENERAL -- 1. Ethical Considerations and Regulatory Issues -- Introduction -- Ethical Concepts -- Moral Theories -- Descriptive Laboratory Animal Use Ethics -- Ethical Principles -- Respect for Life -- Societal Benefit -- Non-Maleficence -- The Three Rs (Replacement, Reduction, and Refinement) -- Replacement -- Reduction -- Refinement -- Ethical Challenges -- Breeding Colonies -- Genetically Modified Rodents -- Cancer Research -- Perinatal Animal Use -- Neuroscience and Behavioral Research -- Food and Fluid Restriction -- Neuroanatomic Studies -- Neural Injury and Disease -- Behavioral Studies -- Prolonged Restraint and Anesthesia -- Restraint of Awake Animals -- Prolonged Studies in Anesthetized Animals -- Institutional Animal Welfare Oversight -- Regulations and Non-regulatory Considerations -- United States Regulatory Considerations -- United States Animal Welfare Act -- Public Health Service Policy on Humane Care and Use of Animals -- Food and Drug Administration Good Laboratory Practices -- Interagency Cooperation -- Environmental Protection Agency Good Laboratory Practices -- Non-Regulatory Considerations -- Institute for Laboratory Animal Research -- Guide for the Care and Use of Laboratory Animals (Guide) -- International Regulations, Policies, and Standards -- AAALAC, International -- Canada -- European Union -- Pacific Rim -- Australia -- New Zealand -- Japan -- South Korea -- Philippines -- Thailand -- China -- Taiwan -- Singapore -- Hong Kong -- Conclusion -- References -- 2. Anesthesia and Analgesia -- Pre-anesthetic Preparation -- Physical Examination -- Fasting -- Stabilization -- Regulatory Requirements -- Controlled Substances -- Pharmacology -- Anticholinergics.

Phenothiazines -- Benzodiazepines -- Alpha2-Agonists -- Systemic Analgesics -- Opioids -- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) -- Tramadol -- Gabapentin -- Amantadine -- Local Anesthetics -- Glucocorticoids -- N-Methyl-D-Aspartic Acid (NMDA) Antagonist -- Ketamine -- Tiletamine-Zolazepam -- Propofol -- Barbiturates -- Inhalation Anesthetics -- Anesthesia Circuits -- Induction Chambers -- Breathing Circuits -- Vaporizer Types and Machines -- Ventilators -- Regulatory Monitoring Requirements -- Anesthesia Waste Gas Scavenging -- Anesthesia Monitoring and Support -- Anesthetic Depth -- Respiratory Function -- Cardiovascular Function -- Temperature -- Fluid Therapy -- Intubation -- Surgical Anesthesia -- Post-operative Monitoring and Pain Assessment -- Pain Assessment -- Post-Operative Analgesia -- Post-Operative Monitoring -- References -- 3. Clinical Biochemistry and Hematology -- Introduction -- Clinical Biochemistry -- Introduction -- Sample Collection -- Restraint -- Blood Collection -- Urine Collection -- Carbohydrate Metabolism -- Glucose -- Lipid Metabolism -- Cholesterol -- Triglycerides -- Enzymes -- Alkaline Phosphatase (ALP) -- Alanine Aminotransferase (ALT) -- Aspartate Aminotransferase (AST) -- Lactate Dehydrogenase (LDH) -- Creatine Kinase (CK) -- Sorbitol Dehydrogenase (SDH) -- Amylase -- Glutamate Dehydrogenase (GDH) -- Hormones -- Adrenal Hormones -- Thyroid Hormones -- Reproductive Hormones -- Liver Function -- Enzymes -- Total Bilirubin -- Bile Acids -- Serum Proteins -- Kidney Function -- Blood Urea Nitrogen (BUN) -- Creatinine -- Electrolytes -- Bicarbonate (HCO-3) -- Calcium (Ca) -- Chloride (Cl-) -- Magnesium (Mg2+) -- Phosphorus (P) -- Potassium (K+) -- Sodium (Na+) -- Rabbit -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism.

Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Guinea Pig -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism -- Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Hamster -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism -- Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Other Rodents -- Gerbil -- Sample Collection -- Reference Values and Sources of Variation -- Chinchilla -- Sample Collection -- Reference Values and Sources of Variation -- Degu -- Sample Collection -- Reference Values and Sources of Variation -- Deer Mouse -- Sample Collection -- Reference Values and Sources of Variation -- Dormouse -- Sample Collection -- Reference Values and Sources of Variation -- Kangaroo Rat -- Sample Collection -- Reference Values and Sources of Variation -- Cotton Rat -- Sample Collection -- Reference Values and Sources of Variation -- Sand Rat -- Sample Collection -- Reference Values and Sources of Variation -- Hematology -- Introduction -- Blood Collection and Sample Preparation -- Blood Collection -- Sample Preparation -- Blood Volume -- Total Blood Volume -- Plasma Volume -- Peripheral Blood Cells -- Erythrocytes -- Leukocytes -- Platelets (Thrombocytes) -- Coagulation -- Bleeding Time (BT) -- Prothrombin Time (PT) -- Activated Partial Thromboplastin Time (APTT) -- Thrombin Time (TT) -- Fibrinogen Concentration -- Bone Marrow -- Rabbit -- Sample Collection -- Blood -- Bone Marrow -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Coagulation -- Bone Marrow -- Guinea Pig -- Sample Collection.

Blood -- Bone Marrow -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Bone Marrow -- Hamster -- Sample Collection -- Blood -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Coagulation -- Bone Marrow -- Other Rodents -- Gerbil -- Sample Collection -- Reference Values and Unique Characteristics -- Chinchilla -- Sample Collection -- Reference Values and Unique Characteristics -- Degu -- Deer Mouse -- Sample Collection -- Reference Values and Unique Characteristics -- Dormouse -- Kangaroo Rat -- Sample Collection -- Reference Values and Unique Characteristics -- Cotton Rat -- Sample Collection -- Reference Values and Unique Characterstics -- Sand Rat -- Sample Collection -- Reference Values and Unique Characteristics -- References -- 4. Euthanasia and Necropsy -- Introduction -- Euthanasia -- Introduction and Background -- Chemical Methods -- Inhalants -- Carbon Dioxide -- Carbon Monoxide -- Inhalant Anesthetics -- Inert Gases -- Injectable Agents -- Barbiturates -- Potassium Chloride -- Unacceptable Injectable Agents -- Physical Methods -- Cervical Dislocation -- Captive Bolt -- Decapitation -- Microwave Irradiation -- Euthanasia of the Rabbit -- Euthanasia of the Guinea Pig -- Euthanasia of the Hamster -- Euthanasia of Mice, Rats, and Other Rodents -- Necropsy -- General Considerations -- Preparation for Necropsy -- Necropsy Procedure -- Collection of Blood and Urine Samples -- Exsanguination and Euthanasia -- External Examination -- Dissection, Gross Examination, and Collection of Tissue Samples -- Sectioning of Skin and Examination of Subcutaneous Tissues -- Opening the Abdominal Cavity -- Urogenital Organs -- Spleen, Mesenteric Lymph Nodes, Pancreas, and Digestive Tract -- Liver, GallBladder, Adrenal Glands, and Kidney -- Thoracic Cavity.

Sciatic Nerve, Skeletal Muscle, Bones, and Joints -- Eyes, Brain, and Spinal Cord -- Skin -- Pathology Considerations -- Descriptive Pathology -- Tissues Sampling, Fixation, and Trimming -- References -- 5. Zoonoses and Occupational Health -- Introduction -- Viral Diseases -- Hantavirus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Lassa Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Lymphocytic Choriomeningitis Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rabies Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsial Diseases -- Coxiella burnetii -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsia akari -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsia rickettsii -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Chlamydial Diseases -- Chlamydophyila caviae -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Chlamydophyila psittaci -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Bacterial Diseases -- Bordetella bronchiseptica -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Borrelia burgdorferi (Lyme's Disease) -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Francisella tularensis (Tularemia) -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Leptospira spp. -- Reservoir and Incidence.

Mode of Transmission.