Environmental Chemicals Enzyme Function and Human Disease -- Contents -- Chairman's introduction -- The role of the drug-metabolizing enzymes -- Discussion -- The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver -- Discussion -- Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues -- Discussion -- Induction of enzymes involved in DNA repair and mutagenesis -- Discussion -- Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research -- Discussion -- Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects -- Discussion -- Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins -- Discussion -- General Discussion I -- Regulation of human drug metabolism by dietary factors -- Discussion -- Influence of foreign compounds on formation and disposition of reactive metabolites -- Discussion -- Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites -- Discussion -- Toxicological implications of polymorphic drug metabolism -- Discussion -- Immunologically mediated toxicity -- Discussion -- Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes -- Discussion -- The influence of nutrition and inducers on mechanisms of toxicity in humans and animals -- Discussion -- Influence of environmental chemicals on drug therapy in humans: studies with contraceptive steroids -- Discussion -- General Discussion II -- Vitamin D metabolism in patients treated with phenytoin and phenobarbitone -- Discussion -- Chemical disease in humans: problems in comparative toxicology.

Discussion -- Implications for future studies in humans -- Final General Discussion -- Index of Contributors -- Subject Index.