Cover -- Front Matter -- Preface -- Contents -- List of Abbreviations -- Executive Summary -- 1 Introduction -- 2 Developmental Defects and Their Causes -- 3 Current Practices for Assessing Risk for Developmental Defects and Their Limitations -- 4 Mechanisms of Developmental Toxicity -- 5 Human Genetics and the Human Genome Project -- 6 Recent Advances in Developmental Biology -- 7 Using Model Animals to Assess and Understand Developmental Toxicity -- 8 A Multilevel Approach to Improving Risk Assessment for Developmental Toxicity -- 9 Conclusions and Recommendations -- References -- Appendixes -- Appendix A Glossary -- Appendix B Database Descriptions -- Appendix C Signaling Pathways -- Appendix D Biographical Information on the Committee on Developmental Toxicology -- Index.