Health Effects of Permethrin Impregnated Army Battle-Dress Uniforms -- Copyright -- Preface -- Contents -- Summary -- EXPOSURE ASSESSMENT -- PHARMACOKINETICS -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- DERMAL TOXICITY -- OCULAR TOXICITY -- NEUROTOXICITY -- LIVER TOXICITY -- IMMUNOTOXICITY -- REPRODUCTIVE AND DEVELOPMENTAL TOXICITY -- GENOTOXICITY -- CARCINOGENICITY -- CONCLUSIONS -- 1 Introduction -- 2 Exposure Assessment -- MILITARY NONFIELD PERSONNEL -- MILITARY FIELD PERSONNEL -- GARMENT WORKERS -- RECOMMENDATIONS -- 3 Pharmacokinetics of Permethrin -- ABSORPTION OF PERMETHRIN -- Oral Absorption -- Dermal Absorption -- Absorption in Humans -- Absorption in Animals -- INTERACTIONS -- METABOLISM -- HYDROLYSIS -- OXIDATION -- RELATIONSHIP TO TOXICITY -- ELIMINATION -- DISTRIBUTION -- Tissue Concentrations -- Protein Binding -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- 4 Acute and Short-Term Toxicity of Permethrin -- ACUTE TOXICITY -- Human Studies -- Animal Studies -- SUBACUTE AND SUBCHRONIC TOXICITY -- Oral Exposure -- Mouse -- Rat -- Dog -- Rabbit -- Cow -- Dermal Exposure -- Inhalation Exposure -- CONCLUSIONS -- 5 Dermal and Ocular Toxicity of Permethrin -- DERMAL TOXICITY -- Human Data -- Clinical Trials -- Animal Data -- Acute and Subchronic Effects -- Photochemical Irritation -- OCULAR TOXICITY -- CONCLUSIONS -- Ocular Toxicity -- Dermal Toxicity -- Recommendation -- 6 Neurotoxicity of Permethrin -- HUMAN DATA -- ANIMAL DATA -- Neurotoxic Effects -- Rats -- Hens -- Neurobehavioral Effects -- CONCLUSIONS -- RECOMMENDATIONS -- 7 Liver and Other Organ Toxicity of Permethrin -- LIVER TOXICITY -- Human Data -- Animal Data -- OTHER ORGAN TOXICITY -- Human Data -- Animal Data -- CONCLUSIONS -- 8 Immunotoxicity of Permethrin -- CONCLUSIONS -- RECOMMENDATIONS -- 9 Reproductive and Developmental Toxicity Of Permethrin -- RAT STUDIES.

MOUSE STUDIES -- RABBIT STUDIES -- OTHER STUDIES -- CONCLUSIONS -- 10 Genotoxicity of Permethrin -- GENE MUTATIONS -- CHROMOSOMAL EFFECTS -- OTHER GENOTOXIC EFFECTS -- CONCLUSIONS -- 11 Carcinogenicity of Permethrin -- CARCINOGENICITY STUDIES IN MICE -- ICI Mouse Study -- FMC Mouse Studies -- Burroughs Wellcome Mouse Study -- CARCINOGENICITY STUDIES IN RATS -- ICI Rat Study -- FMC Rat Study -- Burroughs Wellcome Rat Study -- TUMOR PROMOTION STUDIES: SHIMKIN MOUSE LUNG BIOASSAY -- CONCLUSIONS -- CARCINOGENICITY RISK ASSESSMENT -- Hazard Identification -- Dose-Response Assessment -- Risk Characterization -- Military Nonfield Personnel -- Military Field Personnel -- Garment Workers -- Conclusions -- 12 Summary of Recommendations -- EXPOSURE ASSESSMENT -- PHARMACOKINETICS -- DERMAL TOXICITY -- NEUROTOXICITY -- IMMUNOTOXICITY -- GENOTOXICITY -- References -- Appendix A -- QUANTITATIVE RISK ASSESSMENT PERMETHRIN-IMPREGNATED BATTLE DRESS UNIFORM OCTOBER 1989 -- REFERENCES.