Title and Frontmatter -- Preface to the First Edition -- Preface to the Second Edition -- Contributors -- Contents -- 1. History of Chronic Obstructive Pulmonary Disease -- 2. Lung Development -- 3. Epidemiology -- 4. Genetic Risk Factors -- 5. α1-Antitrypsin Deficiency -- 6. Pathobiology of Emphysema -- 7. Vascular Endothelial Growth Factor and its Role in Emphysema and Asthma -- 8. Macrophage Involvement in Chronic Obstructive Pulmonary Disease -- 9. Small Airway Obstruction in Chronic Obstructive Pulmonary Disease -- 10. Environmental Factors in Chronic Obstructive Pulmonary Disease -- 11. Mucus and Mucus-Secreting Cells in Chronic Obstructive Pulmonary Disease -- 12. Other Large-Airway Diseases that Limit Airflow -- 13. Diffuse Interstitial Lung Diseases Resulting in Airflow Limitation -- 14. Bacterial Infection in Chronic Obstructive Pulmonary Disease -- 15. Viral Infections and Chronic Obstructive Pulmonary Disease -- 16. Small Animal Models of Emphysema -- 17. Chronic Airway Disease in Nonhuman Primates -- 18. Imaging of Chronic Obstructive Pulmonary Disease -- 19. Airway Circulation in Chronic Obstructive Pulmonary Disease -- 20. Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease -- 21. Muscle Involvement in Chronic Obstructive Pulmonary Disease -- 22. Osteoporosis -- 23. Systemic Manifestations of Chronic Obstructive Pulmonary Disease -- 24. Biomarkers in Chronic Obstructive Pulmonary Disease -- 25. Exacerbation of Chronic Obstructive Pulmonary Disease -- 26. Medical Therapy for Chronic Obstructive Pulmonary Disease -- 27. Surgical Therapy for Chronic Obstructive Pulmonary Disease -- 28. Rehabilitation -- 29. Stem Cells -- 30. Psychosocial Aspects of Chronic Obstructive Pulmonary Disease -- 31. Telemedicine and Chronic Obstructive Pulmonary Disease -- 32. Chronic Obstructive Pulmonary Disease, the Final Chapter-Lung Cancer.

Epilogue -- Index.