Cover image for Skin Sensitization in Chemical Risk Assessment : IPCS Harmonization Project Document No. 5.
Skin Sensitization in Chemical Risk Assessment : IPCS Harmonization Project Document No. 5.
Title:
Skin Sensitization in Chemical Risk Assessment : IPCS Harmonization Project Document No. 5.
Author:
WHO.
ISBN:
9789240683440
Personal Author:
Physical Description:
1 online resource (90 pages)
Series:
IPCS Harmonization Project Document, No. 5
Contents:
TITLE -- COPYRIGHT -- TABLE OF CONTENTS -- FOREWORD -- ACKNOWLEDGEMENTS -- LIST OF CONTRIBUTORS -- Workshop Report -- Abstracts -- LIST OF ACRONYMS AND ABBREVIATIONS -- SKIN SENSITIZATION IN CHEMICAL RISK ASSESSMENT: REPORT OF A WHO/IPCS INTERNATIONAL WORKSHOP FOCUSING ON DOSE-RESPONSE ASSESSMENT -- 1. INTRODUCTION -- 2. BACKGROUND -- 3. WORKSHOP QUESTIONS -- 4. OUTCOME OF THE WORKING GROUP DISCUSSIONS -- 4.1 Group A: Quantification -- 4.2 Group B: Human data -- 4.3 Group C: Hazard identification experimental test methods -- 5. GENERAL CONCLUSIONS AND RECOMMENDATIONS OF THE WORKSHOP -- 5.1 Conclusions -- 5.2 Recommendations -- REFERENCES -- APPENDIX A: ABSTRACTS -- THE USE OF HUMAN DATA WHEN CONDUCTING DERMAL SENSITIZATION QUANTITATIVE RISK ASSESSMENTS FOR FRAGRANCE INGREDIENTS -- 1. INTRODUCTION -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- APPLICATION OF THE LOCAL LYMPH NODE ASSAY (LLNA) FOR RESPIRATORY SENSITIZERS -- 1. BACKGROUND -- 2. MAIN POINTS -- 3. RESULTS -- 4. DISCUSSION AND CONCLUSIONS -- 5. FUTURE DIRECTIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- INFORMATION DERIVED FROM SENSITIZATION TEST METHODS: TEST SENSITIVITY, FALSE POSITIVES, AND FALSE NEGATIVES -- 1. INTRODUCTION -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- SKIN SENSITIZATION-A REGULATORY OVERVIEW -- 1. INTRODUCTION -- 2. MAIN POINTS -- REFERENCES -- QUANTIFICATION, POTENCY, AND RISK ASSESSMENT: INDUCTION VERSUS ELICITATION -- 1. BACKGROUND -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- UNCERTAINTY FACTORS AND RISK ASSESSMENT FOR SKIN SENSITIZERS -- 1. INTRODUCTION -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- HAZARD IDENTIFICATION (HUMAN DATA) -- 1. INTRODUCTION/BACKGROUND -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES.

CLINICAL EXPERIENCE INFORMING RISK ASSESSMENT -- 1. INTRODUCTION -- 2. MAIN POINTS -- 3. SUMMARY -- 4. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- PERSPECTIVE OF THE UNITED STATES ENVIRONMENTAL PROTECTION AGENCY'S OFFICE OF PESTICIDE PROGRAMS ON ASSESSMENT OF DERMAL SENSITIZATION RISK USING HEXAVALENT CHROMIUM AS A CASE-STUDY -- REFERENCES -- NEW APPROACHES FOR SKIN SENSITIZATION HAZARD IDENTIFICATION: (Q)SARS/EXPERT SYSTEMS -- 1. INTRODUCTION/BACKGROUND -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- NEW APPROACHES FOR HAZARD IDENTIFICATION: THE DEVELOPMENT OF IN VITRO METHODS FOR PREDICTING CONTACT SENSITIZATION POTENTIAL -- 1. BACKGROUND -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- SENSITIZATION POTENCY OF CHEMICALS -- 1. INTRODUCTION -- 2. PREDICTION OF THE SENSITIZATION POTENTIAL OF CHEMICALS -- 3. SENSITIZATION POTENCY AND SENSITIZATION RISK IN HUMANS -- 4. CONCLUSION AND FUTURE DIRECTIONS -- REFERENCES -- NEW APPROACHES TO HAZARD IDENTIFICATION: NONRADIOACTIVE ALTERNATIVES -- 1. INTRODUCTION AND BACKGROUND -- 2. MAIN POINTS -- 3. CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- THE HARMONIZATION PROJECT DOCUMENT SERIES.
Abstract:
This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information. This book will be useful to toxicologists, researchers, regulatory authorities and industry.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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