The Headaches -- Contents -- Preface to the First Edition -- Preface -- SECTION I General Aspects of the Headaches -- History of the Headache -- Classification of Headache -- Epidemiology of Headache -- Impact of the Headache on the Individual and Family -- Societal Burden of the Headache -- The History and Examination of Headache Patients -- Principles of Clinical Pharmacology, Randomized Controlled Clinical Trials, and Evidence-Based Medicine in Headache -- Ethical Issues in Headache Research and Management -- SECTION II Basic Science Aspects of the Headaches -- Anatomy of Muscles, Tendons, Joints, Blood Vessels, and Meninges -- Anatomy and Physiology of Head Pain -- Inhibition and Facilitation of Nociception -- Peripheral and Central Sensitization Related to Headaches -- Imaging Pain -- Serotonin and Other Biogenic Amines -- Nitric Oxide -- Calcitonin Gene-Related Peptide and Other Peptides -- Sex Hormones -- Prostanoids and Other Inflammatory Mediators -- Other Molecules Involved in Pain Transmission -- Ion Channels Relevant to Pain -- Triptan Signal Transduction -- Animal Models of Headache -- Human Models of the Headaches -- SECTION III The Migraines -- The Migraines: Introduction -- Epidemiology of Migraine -- Migraine Comorbidity -- Migraine Mechanisms -- Genetics of Migraine -- Spreading Depression -- 5-Hydroxytryptamine Involvement in Migraines -- Nitric Oxide Involvement in Migraines -- CGRP Involvement in Migraines -- Channelopathies and Their Possible Relation to Migraines -- Neurogenic Inflammatory Mechanisms -- Blood and Spinal Fluid in Migraines -- Influence of Female Hormones on Migraines -- Platelets and Immunology of Migraines -- Hemodynamics and Neuroimaging of Migraines -- Brain Metabolism in Migraines -- Neurophysiology of Migraines -- Autonomic Dysfunction in Migraines -- Psychological Mechanisms of Migraines.

Synthesis of Migraine Mechanisms -- Migraine: Clinical Features -- Symptomatology of Migraines without Aura -- Migraines with Aura and Their Subforms -- Diagnosis and Differential Diagnosis of Migraines -- Prognosis of Migraines -- Migraine: Management -- General and Pharmacologic Approach to Migraine Management -- Psychological and Behavioral Treatments of Migraines -- Migraine: Acute Drug Treatment of the Attack -- Nonsteroidal Anti-Inflammatory Drugs in the Acute Treatment of Migraines -- Ergot Alkaloids in the Acute Treatment of Migraines -- Triptans, 5-HT1B/1D Receptor Agonists in the Acute Treatment of Migraines -- Antiemetic, Prokinetic, Neuroleptic, and Miscellaneous Drugs in the Acute Treatment of Migraines -- Prioritizing Acute Pharmacotherapy of Migraines -- Migraine: Prophylactic Drug Management -- β-Adrenoceptor Blocking Drugs in Migraine Prophylaxis -- Antiserotonin Drugs in Migraine Prophylaxis -- Calcium Antagonists in Migraine Prophylaxis -- Antiepileptic Drugs in Migraine Prophylaxis -- Nonsteroidal Anti-Inflammatory andMiscellaneous Drugs in Migraine Prophylaxis -- Prioritizing Prophylactic Treatment of Migraines -- Potential New Drugs for Acute and Prophylactic Treatment of Migraines -- Migraine: Special Types and Complications -- Sporadic and Familial Hemiplegic Migraines -- Basilar Migraines and Retinal Migraines -- Status Migrainosus -- Migrainous Infarction and Migraine Triggered Epilepsy -- Chronic Migraines -- SECTION IV Tension-Type Headaches, Cluster Headaches, and Other Primary Headaches -- Tension-Type Headache: Introduction -- Epidemiology of Tension-TypeHeadaches -- Tension-Type Headache: Pathophysiology -- Genetics of Tension-Type Headaches -- Human Studies of Experimental Pain From Muscle -- Sensitization of Myofascial Pain Pathways in Tension-Type Headaches -- Neurophysiology of Tension-Type Headaches.

Hemodynamics and Muscle Metabolism of Tension-Type Headaches -- Temporomandibular Disorders and Tension-Type Headache -- Psychological Mechanisms of Tension-Type Headaches -- Biochemistry of Blood and Cerebrospinal Fluid in Tension-Type Headaches -- Synthesis of Tension-Type Headache Mechanisms -- Tension-Type Headache: Clinical Features -- Symptomatology of Episodic Tension-Type Headaches -- Symptomatology of Chronic Tension-Type Headaches -- Differential Diagnosis and Prognosis of Tension-Type Headaches -- Tension-Type Headache: Management -- General Approach to Treatment of Tension-Type Headaches -- Psychological Treatments of Tension-Type Headaches -- Physiotherapy of Tension-Type Headaches -- Acute Pharmacotherapy of Tension-Type Headaches -- Prophylactic Pharmacotherapy of Tension-Type Headache -- Cluster Headache -- Cluster Headaches: Introduction and Epidemiology -- Genetics of Cluster Headaches -- Anatomy and Pathology of Cluster Headaches -- Biochemistry, Circannual and Circadian Rhythms, Endocrinology, and Immunology of Cluster Headaches -- Neurophysiology and Autonomic Dysfunction in Cluster Headaches -- Neuroimaging in Trigeminal Autonomic Cephalgias -- Synthesis of Cluster Headache Pathophysiology -- Symptomatology of Cluster Headaches -- Diagnosis, Differential Diagnosis, and Prognosis of Cluster Headaches -- General Approach to the Management of Cluster Headaches -- Acute Treatment of Cluster Headaches -- Preventive and Surgical Management of Cluster Headaches -- Paroxysmal Hemicrania -- Sudden Unilateral Neuralgiform Pain with Conjunctival Injection and Tearing -- Other Primary Headaches -- Primary Stabbing, Cough, Exertional, and Thunderclap Headaches -- Primary Headache Attributed to Sexual Activity -- Hypnic Headaches -- Hemicrania Continua -- New Daily Persistent Headache -- SECTION V The Secondary Headaches.

The Secondary Headaches: Introduction -- Acute Posttraumatic Headaches -- Chronic Posttraumatic Headaches -- Headache Attributed to Whiplash Injury -- Headache Attributed to Vascular Disorder -- Ischemic Stroke and Spontaneous Intracerebral Hematoma -- Unruptured Vascular Malformation and Subarachnoid Hemorrhage -- Arteritis -- Carotid or Vertebral Artery Pain -- Cerebral Venous Thrombosis -- Headache Attributed to Nonvascular Intracranial Disorder -- High Cerebrospinal Fluid Pressure -- Low Cerebrospinal Fluid Pressure -- Pseudomigraine with Pleocytosis -- Intracranial Neoplasms -- Headache Attributed to a Substance, an Infection, or a Disorder of Homeostasis -- Headache Associated with Acute Substance Use or Exposure -- Medication Overuse Headaches -- Headache Attributed to Infection -- Headache Attributed to a Disorder of Homeostasis -- Headache or Facial Pain Attributed to a Cranial, Cervical, or Psychiatric Disorder -- Disorder of the Skull and Cervical Spine -- Ocular Disorder -- Disorder of Ear, Nose, and Sinus -- Headache Attributed to Orofacial/Temporomandibular Pathology -- Headache Attributed to Psychiatric Disorder -- Cranial Neuralgias, Nerve Trunk Pain, and Deafferentation Pain -- Pain of Cranial Nerve and Cervical Nerve Origin Other Than Primary Neuralgias -- Trigeminal Neuralgia and Other Facial Neuralgias -- Central Pain in the Face and Head -- SECTION VI Headaches in Children and Adolescents -- History and Examination of Infants, Children, and Adolescents with Headaches -- Childhood Migraine and Related Syndromes -- Tension-Type Headaches and Other Nonmigraine Primary Headaches in the Pediatric Population -- Secondary Headaches in the Pediatric Population -- SECTION VII Special Problems in the Headaches and Their Management -- Headaches During Pregnancy and Lactation -- Headaches and Sleep -- Headaches in the Elderly.

Headache in Patients with Coexisting Other Pain Disorder -- Headaches in Patients with Coexisting Psychiatric Disease -- Headaches in Patients with Coexisting Medical Disease -- Headaches in the Emergency Room -- Index.