FrontMatter -- Preface -- Acknowledgment of Reviewers -- Contents -- Executive Summary -- 1 Introduction -- 2 21st Century Biology -- 3 On the Nature of Biological Data -- 4 Computational Tools -- 5 Computational Modeling and Simulation as Enablers for Biological Discovery -- 6 A Computational and Engineering View of Biology -- 7 Cyberinfrastructure and Data Acquisition -- 8 Biological Inspiration for Computing -- 9 Illustrative Problem Domains at the Interface of Computing and Biology -- 10 Culture and Research Infrastructure -- 11 Conclusions and Recommendations -- Appendixes -- A The Secrets of Life: A Mathematician's Introduction to Molecular Biology -- B Challenge Problems in Bioinformatics and Computational Biology from Other Reports -- C Biographies of Committee Members and Staff -- What Is CSTB?.