Pt. 1. An introduction to immunobiology and innate immunity. Basic concepts in immunology. Innate immunity -- Pt. 2. The recognition of antigen. Antigen recognition by B-cell and T-cell receptors. The generation of lymphocyte antigen receptors. Antigen presentation to T lymphocytes -- Pt. 3. The development of mature lymphocyte receptor repertoires. Signaling through immune system receptors. The development and survival of lymphocytes -- Pt. 4. The adaptive immune response. T cell-mediated immunity. The humoral immune response. Adaptive immunity to infection -- Pt. 5. The immune system in health and disease. Failures of host defense mechanisms. Allergy and hypersensitivity. Autoimmunity and transplantation. Manipulation of the immune response -- Pt. 6. The origins of immune responses. Evolution of the innate immune system.