TABLE OF CONTENTS -- INTRODUCTION -- Part I. Experimental Investigations -- Chapter 1. PHYSIOLOGICAL LAWS CONCERNING AUTONOMIC IMBALANCE -- (A) Summation Processes in the Autonomic Nervous System -- (1) Sympathetic Spatial Summation -- (2) Sympathetic Temporal Summation -- (3) Parasympathetic Summation -- (B) Studies on the Reactivity of the Autonomic Nervous System in Reflexly Induced States of Imbalance -- (1) The Action of Sympathetic Stimuli during Sympathetic Reflex Tuning -- (2) The Action of Parasympathetic Stimuli during Parasympathetic Reflex Tuning -- (3) Autonomic Tuning and Reciprocal Innervation -- (a) PARASYMPATHETIC TUNING AND SYMPATHETIC REACTIVITY -- (b) SYMPATHETIC TUNING AND PARASYMPATHETIC REACTIVITY -- (c) TUNING AND SUCCESSIVE INDUCTION -- (4) Reversal of Autonomic Effects as the Result of Tuning -- (5) Sino-Aortic Reflexes, Tuning, and Autonomic Summation Processes -- (a) AUTONOMIC TUNING AND SINO-AORTIC REFLEXES -- (b) REVERSAL AND INHIBITION OF CENTRALLY INDUCED SYMPATHETIC EXCITATION THROUGH SINO-AORTIC REFLEXES -- (c) MODIFICATION OF AUTONOMIC SUMMATION PROCESSES THROUGH SINO-AORTIC REFLEXES -- (d) HEMORRHAGE AND AUTONOMIC TUNING -- (e) DEXTRAN AND AUTONOMIC TUNING -- (f) AUTONOMIC TUNING AND BLOOD PRESSURE VARIATIONS INDUCED BY NORADRENALINE -- (g) MUTUAL INFLUENCES BETWEEN THE PARASYMPATHETIC AND SYMPATHETIC SYSTEMS -- (6) The Action of Chemoreceptors on the Autonomic Nervous System -- (a) ANOXIA, HYPERCAPNIA, AND HYPOGLYCEMIA AND THE BALANCE OF THE AUTONOMIC NERVOUS SYSTEM -- (b) ASPHYXIA AND AUTONOMIC BALANCE -- (C) Interpretation -- (1) The Laws of Summation, Limiting Mechanisms, and the Dominance of the Sympathetic System -- (2) The Tuning of the Autonomic Nervous System through Baroreceptor Reflexes from the Sino-Aortic Area -- (3) Further Characteristics of the Tuning Process.

(4) The Physiological Basis of the Reversal Phenomenon -- (5) Successive Autonomic Induction -- (6) Sino-Aortic Denervation and the Autonomic Nervous System -- (7) Tuning of the Autonomic Nervous System through a Change in the Internal Environment -- Chapter 2. HYPOTHALAMIC EXCITABILITY, PHASIC AUTONOMIC REFLEXES, AND TONIC AUTONOMIC FUNCTIONS -- (A) A Basic Clinical Observation -- (B) The Dependence of the Action of Mecholyl and Other Hypotensive Drugs on the Excitability of the Posterior Hypothalamus -- (1) The Intrahypothalamic Action of Metrazol and Strychnine -- (2) The Intrahypothalamic Action of Pentothal and Procaine -- The Effect of Physiological Changes in the Excitability of the Hypothalamus -- The Effect of Lesions of the Posterior Hypothalamus -- (C) The Influence of the Excitability of the Anterior Hypothalamus on the Action of Noradrenaline -- (1) The Action of Pentothal -- (2) The Effect of Lesions in the Anterior Hypothalamus -- (D) Reciprocal Innervation and Hypothalamic Autonomic Imbalance -- (E) The Tonic Action of the Hypothalamus on the Blood Pressure and Heart Rate -- (F) Interpretation -- (1) Summation Processes in Conditions of Central Autonomic Imbalance -- (2) Tests of Hypothalamic Excitability and Indicators of Autonomic Balance -- (3) Reciprocal Innervation in States of Centrally Induced Autonomic Imbalance -- (4) The Tonic Functions of the Hypothalamus -- Chapter 3. THE RELATION OF HYPOTHALAMIC EXCITATION TO NEUROGENIC AND HORMONAL (ADRENOMEDULLARY) DISCHARGES. A Contribution to the Study of Homeostasis -- (A) The Relation between Sympathetic and Sympathetico-Adrenal Discharges -- (B) The Influence of Central Sympathetic and Sympathetico-Adrenal Discharges on the Action of Hypotensive Drugs -- (C) The Homeostatic Action of Adrenomedullary Secretion and Its Significance for the Action of Mecholyl.

(D) Noradrenaline, Adrenaline, and the Action of Hypotensive Drugs -- (E) Factors Altering the Relative Dominance of Neurogenic Sympathetic and Hormonal (Adrenomedullary) Discharges -- (F) Interpretation -- Chapter 4. THE TONE OF THE SKELETAL MUSCLES IN ITS RELATION TO THE EXCITABILITY OF THE HYPOTHALAMUS AND THE EMOTIONS -- (A) Proprioception and the Excitability of the Hypothalamus -- (B) Proprioception and the Emotions -- (C) Evaluation -- Chapter 5. ON THE RELATION OF THE HYPOTHALAMUS TO THE VISCERA -- (A) Autonomic Effects on the Bladder and Gut -- (B) The Hypothalamus and Intestinal Activity -- (C) Evaluation -- Chapter 6. RESPIRATORY REFLEXES AND THE HYPOTHALAMUS -- (A) The Hypothalamus and the Level of Respiratory Activity -- (B) Respiratory Reflexes and the Posterior Hypothalamus -- (C) Evaluation -- Chapter 7. THE HYPOTHALAMIC-CORTICAL DISCHARGE AND ITS RELATION TO THE STATE OF THE HYPOTHALAMIC BALANCE -- (A) Proof of the Existence of the Hypothalamic-Cortical Discharge -- (B) The Physiological Significance of the Hypothalamic-Cortical Discharge -- (C) The Dependence of the Hypothalamic-Cortical Discharge on the Excitability of the Hypothalamus -- (D) The Dependence of the Hypothalamic-Cortical Discharge on the Autonomic Balance of the Hypothalamus -- (E) The Relation of Baroreceptor Reflexes to the Hypothalamic-Cortical System -- (1) Hypotensive Drugs and Their Relation to the Hypothalamic-Cortical System -- (2) Hypertensive Drugs and Their Relation to the Hypothalamic-Cortical System -- (F) The Cortico-Hypothalamic Discharge in Hypothalamic Imbalance -- (G) Evaluation -- Chapter 8. EXPERIMENTS ON THE ACTION OF DRUGS ON THE HYPOTHALAMIC-CORTICAL SYSTEM -- (A) Observations on the Reactivity of the Hypothalamus in the Unanesthetized Animal -- (B) The Action of Barbiturates and Chlorpromazine on Cortical and Hypothalamic Potentials.

(C) Drug Action in Hypothalamic Imbalance -- (D) The Caudate Nucleus, the Recruiting Response, and the Action of Drugs -- (E) Evaluation -- Part II. Review of Results and Clinical Application -- Chapter 9. THE EXPERIMENTAL FOUNDATION AND THE CLINICAL APPLICATION OF THE CONCEPT OF PARASYMPATHETIC AND SYMPATHETIC TUNING OF THE AUTONOMIC NERVOUS SYSTEM -- (A) Review of Physiological Experiments -- (B) Application -- Chapter 10. THE EXPERIMENTAL FOUNDATION AND THE CLINICAL APPLICATION OF THE MEASUREMENT OF HYPOTHALAMIC IMBALANCE IN THE INTACT ORGANISM -- (A) Review of Experimental Results -- (B) Physiological and Clinical Investigations on the Mecholyl and Noradrenaline Tests in Man -- Chapter 11. THE HYPOTHALAMIC-CORTICAL SYSTEM IN HYPOTHALAMIC IMBALANCE. Review and Clinical Application -- Chapter 12. THE PHYSIOLOGY OF FEAR AND ANGER -- (A) Funkenstein's Work -- (B) Physiological Considerations -- (C) Further Studies on Human Emotions -- (D) Concluding Remarks -- Chapter 13. THE ROLE OF THE HYPOTHALAMUS IN HOMEOSTASIS -- (A) Noradrenaline and Adrenaline in Homeostasis -- (B) Homeostasis and Hypothalamic Imbalance -- SUMMARY AND CONCLUSIONS -- EPILOGUE -- BIBLIOGRAPHY -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- M -- N -- P -- R -- S -- T -- U -- V.