Contents -- 1. Introduction -- 1.1 Philosophy -- 1.2 Organization -- References -- 2. Cell Surface Receptor/Ligand Binding Fundamentals -- 2.1 Background -- 2.1.1 Experimental methods -- 2.1.2 Effects of extrinsic variables -- 2.1.3 Receptor mobility in cell membranes -- 2.2 Cell Surface Receptor Binding Models -- 2.2.1 Simple monovalent binding -- 2.2.2 True and apparent cooperativity -- 2.2.3 Multiple receptor states -- 2.2.4 Ternary complex formation and receptor aggregation -- Nomenclature -- References -- 3 Receptor/Ligand Trafficking -- 3.1 Background -- 3.1.1 Endocytic cycle -- 3.1.2 Experimental methods -- 3.2 Mathematical Models -- 3.2.1 Whole-cell kinetic models -- 3.2.2 Mechanistic models for individual trafficking processes -- Nomenclature -- References -- 4. Physical Aspects of Receptor/Ligand Binding and Trafficking Processes -- 4.1 Probabilistic aspects of binding -- 4.1.1 Fluctuations in ligand concentration -- 4.1.2 Fluctuations in kinetic binding processes -- 4.2 Diffusion Effects -- 4.2.1 Ligand binding to solution receptors -- 4.2.2 Ligand binding to cell surface receptors -- 4.2.3 Receptor coupling with membrane molecules -- 4.2.4 Applications -- 4.2.5 Intermolecular effects on diffusion -- 4.3 Multivalent Binding and Receptor Crosslinking -- 4.3.1 Bivalent ligand/monovalent receptor -- 4.3.2 Multivalent ligand/monovalent receptor -- 4.3.3 Bivalent ligand/bivalent receptor -- Nomenclature -- References -- 5 Signal Transduction -- 5.1 Background -- 5.1.1 Classes of receptor activity -- 5.1.2 Second messengers -- 5.1.3 G-proteins -- 5.1.4 Receptors as enzymes -- 5.1.5 Desensitization or adaptation of the cellular response -- 5.2 Models of Receptor/G-Protein/Effector Interactions -- 5.2.1 Activation of adenylate cyclase and production of cAMP -- 5.2.2 Activation of phospholipase C and the production of calcium.

5.2.3 Details of G-protein activation -- 5.3 Model for Receptors as Enzymes -- 5.4 Models for Adaptation -- 5.4.1 Simple kinetic models -- 5.4.2 Consequence of complete adaptation -- Nomenclature -- References -- 6 Receptor-Mediated Cell Behavioral Responses -- 6.1 Cell Proliferation -- 6.1.1 Background -- 6.1.2 Experimental methods -- 6.1.3 Models -- 6.2 Cell Adhesion -- 6.2.1 Background -- 6.2.2 Experimental methods -- 6.2.3 Physical aspects -- 6.2.4 Equilibrium models -- 6.2.5 Dynamic models -- 6.3 Cell Migration -- 6.3.1 Background -- 6.3.2 Experimental methods -- 6.3.3 Mathematical Models -- Nomenclature -- References -- 7. Future Directions -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- R -- S -- T -- V.