part PART ONE Bioavailability and metabolic aspects of industrial chemicals -- chapter 1 Biomonitoring and Absorption of Industrial Chemicals: the Challenge of Organic Solvents / chapter 2 Toxicokinetics and Biodisposition of Industrial Chemicals / chapter 3 Metabolic Activation of Industrial Chemicals and Implications for Toxicity / chapter 4 Sizing up the Problem of Exposure Extrapolation: New Directions in Allometric Scaling / part PART TWO Reactive industrial chemicals -- chapter 5 Metabolism of Reactive Chemicals / chapter 6 Methods for the Determination of Reactive Compounds -- part PART THREE Pulmonary toxicology of industrial chemicals -- chapter 7 Studies to Assess the Carcinogenic Potential of Man-Made Vitreous Fibers / chapter 8 Pulmonary Toxicity Studies with Man-made Organic Fibres: Preparation and Comparisons of Size-separated Para-aramid with Chrysotile Asbestos Fibres. / chapter 9 Pulmonary Hyperreactivity to Industrial Pollutants / chapter 10 Mechanisms of Pulmonary Sensitization / chapter 11 Occupational Asthma Induced by Chemical Agents / part PART FOUR Biomarkers and risk assessment of industrial chemicals -- chapter 12 Biomarkers and Risk Assessment / chapter 13 Extrapolation of Toxicity Data and Assessment of Risk / chapter 14 Molecular Approaches to Assess Cancer Risks / chapter 15 Evaluation of Toxicity to the Immune System / chapter 16 New Strategies: the Use of Long-term Cultures of Hepatocytes in Toxicity Testing and Metabolism Studies of Chemical Products Other than Pharmaceuticals. / part PART FIVE Mechanisms of toxicity of industrial chemicals -- chapter 17 Peroxisome Proliferation / chapter 18 Neurotoxicity Testing of Industrial Compounds: in vivo Markers and Mechanisms of Action / chapter 19 Endocrine Toxicology of the Thyroid for Industrial Compounds / chapter 20 Testing and Evaluation for Reproductive Toxicity / part PART SIX Toxicity of selected classes of industrial chemicals -- chapter 21 Special Points in the Toxicity Assessment of Colorants (Dyes and Pigments) / chapter 22 Toxicology of Textile Chemicals / chapter 23 Antioxidants and Light Stabilisers : Toxic Effects of 3,5-Di-alkyl-4hydroxyphenyl Propionic Acid Derivatives in the Rat and their Relevance for Human Safety Evaluation. -- chapter 24 Toxicology of Surfactants: Molecular, Mechanistic and Regulatory Aspects / part PART SEVEN Controversial mechanistic and regulatory issues in the safety assessment of industrial chemicals. -- chapter 25 Low Dose of a Genotoxic Carcinogen does not ‘Cause’ Cancer; it Accelerates Spontaneous Carcinogenesis / chapter 26 Controversial Mechanistic and Regulatory Issues in Safety Assessment of Industrial Chemicals—an Industry Point of View.