CONTENTS -- 1. BRAIN TUMOR CLASSIFICATION, GRADING, AND EPIDEMIOLOGY -- CLASSIFICATION AND GRADING -- Historical Origins -- Neuroepithelial Tumors -- Tumors of Cranial and Peripheral Nerves -- Mesenchymal Tumors -- Lymphomas -- Germ Cell Tumors -- Sellar Region Tumors -- Cysts and Other Benign Tumorlike Lesions -- Brain Extension of Neighboring Regional Tumors -- Metastatic Tumors -- EPIDEMIOLOGY -- Incidence -- Environmental Exposure -- Genetics -- 2. BRAIN TUMOR BIOLOGY -- GLIAL DIFFERENTIATION -- T1A Precursor Differentiation -- O2A Precursor Differentiation -- Gene Activation -- Glial Oncogenesis -- ANGIOGENESIS -- Growth Factors and Angiogenesis -- Inhibition of Angiogenesis -- BLOOD-BRAIN BARRIER -- Structure -- Function -- Drug Delivery to Tumor -- Disruption -- CHROMOSOMAL CHANGES -- Astrocytoma -- Oligodendroglioma -- Primitive Neuroectodermal Tumor -- Meningioma -- GROWTH FACTORS, RECEPTORS, AND CYTOKINES -- Growth Factors and Receptors -- Kinase Receptors -- Cytokines -- INVASION -- Extracellular Matrix -- Adhesion Molecules and Receptors -- Proteases and Their Natural Inhibitors -- CELL KINETICS AND PROLIFERATIVE INDICES -- Cell Kinetics -- Proliferative Indices -- DRUG SENSITIVITY AND RESISTANCE -- Sensitivity -- Resistance -- 3. TUMOR IMAGING AND RESPONSE -- TUMOR IMAGING -- Static Imaging Techniques -- Dynamic Imaging Techniques -- Co-registration of Images and Treatment Planning -- TUMOR TREATMENT AND IMAGING -- Determination of Tumor Margins -- Timing of Scans -- Definition of Response -- Pitfalls in Response Determination -- 4. SURGERY FOR BRAIN TUMORS -- GENERAL PRINCIPLES -- OPEN SURGERY -- STEREOTACTIC SURGERY -- ENDOSCOPIC SURGERY -- 5. RADIATION THERAPY FOR BRAIN TUMORS: CURRENT PRACTICE -- MECHANISMS OF RADIOTHERAPY -- PRINCIPLES OF RADIOTHERAPY -- Radiation Fractionation -- Radiation Therapy Techniques.

TOLERANCE OF THE BRAIN TO RADIATION THERAPY -- RADIATION NECROSIS -- EFFECTS OF RADIOTHERAPY ON INTELLIGENCE -- 6. RADIATION THERAPY FOR BRAIN TUMORS: RECENT ADVANCES AND EXPERIMENTAL METHODS -- CONFORMAL RADIOTHERAPY -- RADIOSURGERY -- INTERSTITIAL BRACHYTHERAPY -- BORON NEUTRON CAPTURE THERAPY -- 7. BRAIN TUMOR CHEMOTHERAPY AND IMMUNOTHERAPY -- CHEMOTHERAPY -- Principles -- Clinical Trials -- Brain Cancer Chemotherapy Drugs and Toxicity -- Innovative Approaches for Chemotherapy -- IMMUNOTHERAPY -- Principles -- Types -- 8. MALIGNANT ASTROCYTOMA -- HISTORY AND NOMENCLATURE -- EPIDEMIOLOGY -- BIOLOGY -- Chromosomal Changes -- Growth Factors -- Cell Surface Receptors and Malignant Astrocytoma Growth and Invasion -- Growth Kinetics -- PATHOLOGY -- CLINICAL SYMPTOMS -- DIFFERENTIAL DIAGNOSIS -- DIAGNOSTIC WORKUP -- TREATMENT -- Symptomatic -- Surgery -- Radiation Therapy -- Chemotherapy -- Immunotherapy -- Gene Therapy -- PROGNOSIS AND COMPLICATIONS -- Prognosis -- Complications -- Quality of Life -- 9. PILOCYTIC ASTROCYTOMA, LOW-GRADE ASTROCYTOMA, AND OTHER "BENIGN" NEUROEPITHELIAL NEOPLASMS -- PILOCYTIC ASTROCYTOMA -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- LOW-GRADE ASTROCYTOMA -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- OTHER "BENIGN" NEUROEPITHELIAL NEOPLASMS -- Subependymal Giant Cell Astrocytoma -- Pleomorphic Xanthoastrocytoma -- Gangliocytoma and Ganglioglioma -- Desmoplastic Infantile Ganglioglioma -- Dysembryoplastic Neuroepithelial Tumor -- Central Neurocytoma -- 10. OLIGODENDROGLIOMA AND OLIGO-ASTROCYTOMA -- HISTORY AND NOMENCLATURE -- EPIDEMIOLOGY -- BIOLOGY.

PATHOLOGY -- CLINICAL SYMPTOMS -- DIFFERENTIAL DIAGNOSIS -- DIAGNOSTIC WORKUP -- TREATMENT -- Surgery -- Radiation Therapy -- Chemotherapy -- PROGNOSIS AND COMPLICATIONS -- Prognosis -- Complications -- 11. POSTERIOR FOSSA TUMORS -- MEDULLOBLASTOMA (PRIMITIVE NEUROECTODERMAL TUMOR) -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- EPENDYMOMA -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- BRAINSTEM GLIOMAS -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- CEREBELLAR PILOCYTIC ASTROCYTOMAS (SEE CHAPTER 9) -- CHOROID PLEXUS PAPILLOMAS -- DERMOID AND EPIDERMOID CYSTS -- SUBEPENDYMOMA -- 12. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA -- HISTORY AND NOMENCLATURE -- EPIDEMIOLOGY -- BIOLOGY -- PATHOLOGY -- CLINICAL SYMPTOMS -- DIFFERENTIAL DIAGNOSIS -- DIAGNOSTIC WORKUP -- TREATMENT -- Surgery -- Radiation Therapy -- Chemotherapy -- PROGNOSIS AND COMPLICATIONS -- Prognosis -- Complications -- 13. PITUITARY AND PINEAL REGION TUMORS -- PITUITARY TUMORS -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Syndromes -- Diagnostic Workup -- Differential Diagnosis -- Treatment -- Prognosis and Complications -- PINEAL REGION TUMORS -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Syndromes -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- 14. EXTRA-AXIAL BRAIN TUMORS -- ACOUSTIC NEURINOMA -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms.

Differential Diagnosis -- Diagnostic Workup -- Treatment and Prognosis -- Complications -- MENINGIOMAS -- History and Nomenclature -- Epidemiology -- Biology -- Pathology -- Clinical Symptoms -- Differential Diagnosis -- Diagnostic Workup -- Treatment -- Prognosis and Complications -- SKULL-BASE TUMORS -- Chordoma and Chondrosarcoma -- Glomus Tumors -- Paranasal Sinus Carcinoma -- Pituitary Adenoma -- Acoustic Neurinoma -- Meningioma -- 15. BRAIN METASTASES -- HISTORY AND NOMENCLATURE -- EPIDEMIOLOGY -- BIOLOGY -- PATHOLOGY -- CLINICAL SYMPTOMS -- DIFFERENTIAL DIAGNOSIS -- DIAGNOSTIC WORKUP -- TREATMENT -- Symptomatic -- Surgery -- Radiation Therapy -- Chemotherapy -- PROGNOSIS -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.