Microbial natural products : a past with a future -- New concepts and approaches to biodiversity -- Nature products drug discovery at the National Cancer Institute : past achievements and new directions for the new millennium -- Secondary metabolites as a vital source of animal health products -- The relationship between natural products and synthetic chemistry in the discovery process -- Natural products vs. combinatorials : a case study -- Mushrooms, microbes and medicines -- Signal transduction inhibitors from microorganisms -- Novel inhibitors of lipoprotein associated phospholipase A2 produced by Pseudomonas fluorescens DSM 11579 -- Marine organisms as a source of novel lead structures for drug development -- The anticancer dolastatins as cyanobacterial metabolites -- A Cu{esc}p2+{esc}s selective marine metabolite -- Water soluble bioactive alkaloids -- "Lessons from nature" : can ecology provide new leads in the search for novel bioactive chemicals from tropical rainforests? -- Brazilian biodiversity : a source of phytomedicines, natural drugs and leads for the pharmaceutical and agrochemical industries -- A modern perspective to the traditional use of plants in the highlands of Scotland -- In vivo and in vitro biosynthetic studies : Understanding and exploiting natural pathways -- Fused ring aromatic polyketides are formed by different cyclisation pathways in fungi and streptomycetes -- The strobilurin fungicides : from mushroom to molecule to market -- A synthesis of (+)prelog-Djerassi lactonic acid -- N-([alpha]-aminoacyl)-5'-O-sulfamoyladenosines : natural product based inhibitors of amino acyl tRNA synthetases.