Clinical Aspects -- Hughes Syndrome: History -- Antiphospholipid (Hughes) Syndrome: An Overview -- Epidemiology of Antiphospholipid Syndrome -- Hemocytopenias in Antiphospholipid Syndrome -- Cardiac Manifestations in Antiphospholipid Syndrome -- Cerebral Ischemia in Antiphospholipid Syndrome -- Cerebral Disease Other than Stroke and Transient Ischemic Attack in Antiphospholipid Syndrome -- Skin Manifestations of Antiphospholipid Syndrome -- Kidney Disease in Antiphospholipid Syndrome -- Systemic Hypertension in Antiphospholipid Syndrome -- Pulmonary Hypertension and Antiphospholipid Antibodies -- Osteoarticular Manifestations of Antiphospholipid Syndrome -- The Ear and Antiphospholipid Syndrome -- The Eye in Primary Antiphospholipid Syndrome -- Primary Antiphospholipid Syndrome -- Catastrophic Antiphospholipid Syndrome -- Obstetric Antiphospholipid Syndrome -- Infertility and Antiphospholipid Antibodies -- Transplantation of Solid Organs, Tissues, and Prosthetic Devices in Patients with Antiphospholipid Antibodies -- Antiphospholipid Syndrome in Children -- Ethnic and Geographic Variation in Antiphospholipid Syndrome -- Antiphospholipid Syndrome: Differential Diagnosis -- Laboratory Investigation -- Anticardiolipin Testing -- Lupus Anticoagulants: Mechanistic and Diagnostic Considerations -- ?2-glycoprotein I and Anti-?2-glycoprotein I Antibodies -- Antiprothrombin Antibodies -- Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies -- Basic Aspects -- Vascular Pathology of Antiphospholipid Antibody Syndrome -- Placental Pathology in Antiphospholipid Syndrome -- Antiphospholipid Syndrome — Experimental Models: Insight into Etiology, Pathogenesis, and Treatments -- Antiphospholipid Antibody-Induced Pregnancy Loss and Thrombosis -- Mechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets -- Interaction of Antiphospholipid Antibodies with Endothelial Cells -- The Influence of Antiphospholipid Antibodies on the Protein C Pathway -- Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome -- Annexins in Antiphospholipid Syndrome -- Plasminogen Activation, Fibrinolysis, and Cell Proteolytic Activity in Antiphospholipid Syndrome -- Lessons from Sequence Analysis of Monoclonal Antiphospholipid Antibodies -- Apoptosis and Antiphospholipid Antibodies -- Accelerated Atherogenesis and Antiphospholipid Antibodies -- Genetics of Antiphospholipid Syndrome -- Infection and Drug-Induced Antiphospholipid Antibodies -- Therapy -- Management of Thrombosis in Antiphospholipid Syndrome -- Management of Antiphospholipid Syndrome in Pregnancy -- Management of Thrombocytopenia in Hughes Syndrome -- The Future of Hughes Syndrome.