Biomechatronic Design in Biotechnology: A Methodology for Development of Biotechnological Products -- Contents -- Preface -- 1 Introduction -- 1.1 SCOPE OF DESIGN -- 1.2 DEFINITION OF BIOMECHATRONIC PRODUCTS -- 1.3 PRINCIPLES OF BIOMECHATRONICS -- 1.4 BRIEF HISTORY OF THE DEVELOPMENT OF BIOMECHATRONIC PRODUCTS AND ENGINEERING -- 1.5 AIM OF THIS BOOK -- REFERENCES -- Part I: Fundamentals -- 2 Conceptual Design Theory -- 2.1 SYSTEMATIC DESIGN -- 2.1.1 Design for Products -- 2.1.2 Origin of the Design Tasks -- 2.1.3 Development of Design Thinking -- 2.1.4 Recent Methods -- 2.2 BASICS OF TECHNICAL SYSTEMS -- 2.2.1 Energy, Material, and Signals and Their Conversion -- 2.2.2 Interrelationships of Functions -- 2.2.3 Interrelationship of Constructions -- 2.2.4 Interrelationship of Systems -- 2.3 PSYCHOLOGY IN THE SYSTEMATIC APPROACH -- 2.4 A GENERAL WORKING METHODOLOGY -- 2.4.1 Analysis for Resolving Technical Problems -- 2.4.2 Abstraction of Interrelationships of Systems -- 2.4.3 Synthesis of the Technical System -- 2.5 CONCEPTUAL DESIGN -- 2.6 ABSTRACTION IN ORDER TO IDENTIFY ESSENTIAL PROBLEMS -- 2.7 DEVELOPING THE CONCEPTS -- 2.7.1 Organizing the Development Process -- 2.8 CONCLUDING REMARKS -- REFERENCES -- 3 Biotechnology and Mechatronic Design -- 3.1 TRANSDUCTION OF THE BIOLOGICAL SCIENCE INTO BIOTECHNOLOGY -- 3.2 BIOLOGICAL SCIENCES AND THEIR APPLICATIONS -- 3.3 BIOTECHNOLOGY AND BIOENGINEERING -- 3.4 APPLYING MECHATRONIC THEORY TO BIOTECHNOLOGY: BIOMECHATRONICS -- 3.5 CONCLUSIONS -- REFERENCES -- 4 Methodology for Utilization of Mechatronic Design Tools -- 4.1 IDEA OF APPLYING THE MECHATRONIC DESIGN TOOLS -- 4.2 TABLE OF USER NEEDS -- 4.3 LIST OF TARGET SPECIFICATIONS -- 4.4 CONCEPT GENERATION CHART -- 4.4.1 Basic Concept Component Chart -- 4.4.2 Permutation Chart -- 4.5 CONCEPT SCREENING MATRIX -- 4.6 CONCEPT SCORING MATRIX.

4.7 HUBKA-EDER MAPPING -- 4.7.1 Overview Hubka-Eder Map -- 4.7.2 Zoom-in Hubka-Eder Mapping -- 4.8 FUNCTIONS INTERACTION MATRIX -- 4.8.1 Functions Interaction Matrix for Systems and Subsystems -- 4.8.2 Functions Interaction Matrix for Systems and Transformation Process -- 4.8.3 Design Structure Matrix -- 4.9 ANATOMICAL BLUEPRINT -- 4.10 CONCLUSIONS -- REFERENCES -- Part II: Applications -- 5 Blood Glucose Sensors -- 5.1 BACKGROUND OF BLOOD GLUCOSE ANALYSIS -- 5.2 SPECIFICATION OF NEEDS FOR BLOOD GLUCOSE ANALYSIS -- 5.3 DESIGN OF BLOOD GLUCOSE SENSORS -- 5.3.1 Generation of Sensor Concepts -- 5.4 DESCRIPTION OF THE SYSTEMS INVOLVED IN THE DESIGN CONCEPTS FOR GLUCOSE BLOOD SENSORS -- 5.4.1 Biological Systems -- 5.4.2 Technical Systems -- 5.4.3 Information Systems -- 5.4.4 Management and Goal Systems -- 5.4.5 Human Systems -- 5.4.6 Active Environment -- 5.4.7 Interactions Between the Systems and Functions of the Design -- 5.4.8 Anatomical Blueprints from the Functions Interaction Matrix Analysis -- 5.5 CONCLUSIONS -- REFERENCES -- 6 Surface Plasmon Resonance Biosensor Devices -- 6.1 INTRODUCTION -- 6.2 DESIGN REQUIREMENTS ON SPR SYSTEMS -- 6.2.1 Needs and Specifications of an SPR Design -- 6.3 MECHATRONIC DESIGN APPROACH OF SPR SYSTEMS -- 6.3.1 Generation of Design Alternatives -- 6.3.2 Hubka-Eder Mapping of the Design Alternatives -- 6.4 DETAILED DESIGN OF CRITICAL SPR SUBSYSTEMS -- 6.4.1 Design of the Sensor Surface -- 6.4.2 Design of the Fluidic System -- 6.5 CONCLUSIONS -- REFERENCES -- 7 A Diagnostic Device for Helicobacter pylori Infection -- 7.1 DIAGNOSTIC PRINCIPLE OF HELICOBACTER INFECTION -- 7.2 MECHATRONIC ANALYSIS OF UREA BREATH TEST SYSTEMS -- 7.2.1 Mission and Specification for a Urea Breath Tests -- 7.2.2 Generation of UBT Design Concepts -- 7.2.3 Screening and Scoring of UBT Design Concepts.

7.3 DESCRIPTION OF THE SYSTEMS INVOLVED IN THE DESIGN CONCEPTS FOR THE UREA BREATH TESTS -- 7.3.1 Biological Systems Involved -- 7.3.2 Technical Systems Alternatives -- 7.3.3 Information Systems (SIS) Required -- 7.3.4 Management and Goal Systems Required -- 7.3.5 Human Systems Involved in the Testing -- 7.3.6 Active Environment That Can Influence -- 7.4 ASPECTS OF THE DESIGN FOR EFFICIENT MANUFACTURE -- 7.5 CONCLUSIONS -- REFERENCES -- 8 Microarray Devices -- 8.1 PRINCIPLES, METHODS, AND APPLICATIONS OF MICROARRAYS -- 8.1.1 Principles and Technology -- 8.1.2 Fabrication Methods -- 8.1.3 Companies Developing Microarrays -- 8.1.4 Applications of DNA Microarrays -- 8.2 SPECIFICATION OF NEEDS -- 8.3 DESIGN OF MICROARRAYS -- 8.3.1 Generation of cDNA Microarray Concepts -- 8.4 DESCRIPTION OF THE SYSTEMS INVOLVED IN THE DESIGN CONCEPTS -- 8.4.1 Biological Systems -- 8.4.2 Technical Systems -- 8.4.3 Information System -- 8.4.4 Management and Goal Systems and the Human Systems -- 8.4.5 Active Environment -- 8.4.6 Interaction Analysis -- 8.5 CONCLUSIONS -- REFERENCES -- 9 Microbial and Cellular Bioreactors -- 9.1 BIOREACTOR DEVELOPMENT DURING THE 1970s-1990s -- 9.2 MISSIONS, USER NEEDS, AND SPECIFICATIONS FOR BIOREACTORS -- 9.2.1 Design Mission and User Needs -- 9.2.2 Target Specifications -- 9.3 ANALYSIS OF SYSTEMS FOR CONVENTIONAL BIOREACTORS -- 9.3.1 Biological Systems in the Bioreactor -- 9.3.2 Technical Systems -- 9.3.3 Studying the Interactions of the Systems -- 9.3.4 Penicillin Production in a Metabolically Engineered Penicillium strain (Case 1) -- 9.3.5 A Bioreactor System Producing a Recombinant Protein in CHO Cell Culture (Case 2) -- 9.3.6 Information Systems -- 9.3.7 Management and Goal Systems -- 9.3.8 Human Systems -- 9.3.9 Active Environment -- 9.4 NOVEL BIOREACTOR DESIGNS -- 9.4.1 Microbioreactors -- 9.4.2 Bioreactors with Immobilized Cells.

9.4.3 Bioreactors for Tissue and Stem Cell Cultures -- 9.4.4 Bioreactors for Plant Cell Cultures -- 9.5 CONCLUSIONS -- REFERENCES -- 10 Chromatographic Protein Purification -- 10.1 BACKGROUND OF CHROMATOGRAPHIC PROTEIN PURIFICATION -- 10.2 SPECIFICATION OF NEEDS FOR PROTEIN PURIFICATION SYSTEMS -- 10.3 DESIGN OF PURIFICATION SYSTEMS -- 10.3.1 Generation of Design Alternatives -- 10.3.2 Screening the Design Alternatives -- 10.3.3 Analysis of the Generated Alternatives for a Chromatography System -- 10.3.4 Interactions Between Key Systems and the Transformation Process -- 10.4 UNIT OPERATION PURIFICATION IN A FVIII PRODUCTION PROCESS (CASE 1) -- 10.5 MICROPURIFICATION SYSTEM BASED ON A MULTICHIP DEVICE (CASE 2) -- 10.6 CONCLUSIONS -- REFERENCES -- 11 Stem Cell Manufacturing -- 11.1 STATE OF THE ART OF STEM CELL MANUFACTURING -- 11.2 NEEDS AND TARGET SPECIFICATIONS FOR SCALED-UP STEM CELL MANUFACTURING -- 11.3 SETTING UP AN EFFICIENT MANUFACTURING SYSTEM BY USING BIOMECHATRONIC CONCEPTUAL DESIGN -- 11.3.1 Generating Process Alternatives -- 11.3.2 Hubka-Eder Map for a Human Embryonic Stem Cell Process -- 11.4 CONCLUSIONS -- REFERENCES -- 12 Bioartificial Organ- Simulating Devices -- 12.1 INTRODUCTION -- 12.2 DESIGN OF BIOARTIFICIAL ORGAN-SIMULATION DEVICES -- 12.2.1 Needs and Specifications -- 12.2.2 Evaluation of the Design Concepts -- 12.3 ANALYSIS OF BIOARTIFICIAL LIVER SYSTEMS -- 12.3.1 Biological Systems -- 12.3.2 Technical Systems -- 12.3.3 Information Systems -- 12.3.4 Management and Goals Systems -- 12.3.5 Human Systems -- 12.4 CONCLUSIONS -- REFERENCES -- 13 Applications to Process Analytical Technology and Quality by Design -- 13.1 PAT AND QbD CONCEPTS -- 13.2 NEEDS OF THE PAT/QbD PLAYERS AND RESULTING SPECIFICATIONS -- 13.3 APPLICATION OF DESIGN METHODOLOGY TO PAT/QbD -- 13.3.1 Concept Generation for a PAT/QbD System Structure.

13.3.2 Hubka-Eder Mapping of the PAT/QbD Transformation Process for a Pharmaceutical Process -- 13.3.3 Analysis of Effects -- 13.4 APPLYING MECHATRONIC DESIGN ON A PAT SYSTEM FOR ONLINE SOFTWARE SENSING IN A BIOPROCESS (CASE) -- 13.5 CONCLUSIONS -- REFERENCES -- Glossary -- Index.