Front Cover -- Catecholamine Research in the 21st Century -- Copyright Page -- Contents -- Preface -- THEME A: CATECHOLAMINE BIOSYNTHESIS AND STORAGE -- 1. Genetic Manipulation of Catecholamine Signaling in the Mouse -- 2. AADC Deficiency: Occurring in Humans -- Modeled in Rodents -- Treated in Patients -- 3. Tyrosine Hydrolylase and Dopamine Beta-Hydroxylase: Role of Common Genetic Variation in Adrenergic Responses to Stress and ... -- 4. Pharmacokinetic and Pharmacodynamic Properties of Etamicastat, a New DBH Inhibitor: Comparison to Nepicastat -- 5. Estradiol-Mediated Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes: The Role of Membrane-Initiated Sign... -- 6. Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines -- 7. Unique Regulation of TH Gene Expression in Midbrain Dopamine Neurons -- 8. Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme -- 9. The Peripheral Interaction of Tyrosine Hydroxylase and 14-3-3γ with Negatively Charged Phospholipidic Membranes -- References -- 10. Dynamic Regulation of Tyrosine Hydroxylase Gene Expression by Key Fate-Determining Transcription Factors during Dopaminergi... -- 11. Analysis of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson's Disease -- 12. Non-dopaminergic Neurons Partly Expressing Dopaminergic Phenotype: Functional Significance and Regulation -- 13. Developing Brain as an Endocrine Organ: Catecholamines Secretion and Endocrine Action -- 14. Brainstem DOPAergic System -- 15. Imaging Norepinephrine Transporters in Humans -- Translational Research with PET -- 16. Imaging the Vesicular Monoamine Transporter (VMAT2) in Neurodegenerative Diseases -- 17. GTP Cyclohydrolase Regulation: Implications for Brain Development and Function.

18. Neonatal Diagnosis of Menkes Disease by a Pattern of Plasma Catechols -- 19. Catecholamine Metabolites Affected by the Copper-Dependent Enzyme Dopamine-Beta-Hydroxylase Provide Sensitive Blood and Csf... -- 20. Are the Enzymes of the Catecholamine Biosynthetic Pathway Locally Synthesized in the Axon? -- 21. Effects of Missense Mutations in Tyrosine Hydroxylase (TH) Found in Patients with Neurological Disorders Attributed to TH D... -- 22. Tetrahydrobiopterin Deficiency Impairs Postnatal Increase of TH Protein via Insufficient Dopamine Biosynthesis -- 23. Selective Ablation of Dopamine Beta-Hydroxylase Neurons (Subpopulation of TH Neurons) in the Brain: New Insights into Brain... -- 24. Neural Circuit Mechanism for Learning Dependent on Dopamine Transmission: Roles of Striatal Direct and Indirect Pathways in... -- 25. Regulation of Tyrosine Hydroxylase by Ser19-Phosphorylation-Dependent Binding to 14-3-3γ -- 26. Modeling the Dynamics of Dopamine Biosynthesis and its Regulation by Tyrosine Hydroxylase -- Reference -- 27. Reassessment of Intrinsic Dopaminergic Innervation in the Human Enteric Nervous System - Clinical Implications -- 28. Midbrain Dopamine Neurons are Divided into Different Functional Groups -- 29. Cell-, Region- and Species-Specific Expression of VMAT2: Implications for Medical Imaging With High-Affinity Transporter Li... -- THEME B: CATECHOLAMINE RELEASE AND RE-UPTAKE -- 30. Detecting Catecholamines - A Journey from Beaker to the Behaving Brain -- 31. Functional Disturbances in DA Homeostasis and Signaling Revealed Through the Study of Rare Dopamine Transporter Coding Variants -- 32. Norepinephrine Transporter A457P Knockin Mice Display Tachycardia and Anxiety-Like Behavior -- 33. In Vivo Mutations in the Trafficking Domain of the Drosophila Vesicular Monoamine Transporter Disrupt Specific Amine-Dependent Behaviors.

34. Fate of the Chromaffin Granule Membrane and its Protein Constituents after Fusion -- Acknowledgements -- 35. Catestatin (Human Chromogranin A352-372) Induces Lipolysis and Fatty Acid Oxidation through Regulation of Adrenergic and Leptin Signaling -- 36. Introduction: From Mystery Matrix Proteins to Precise Molecular Actions in Human Disease -- Acknowledgements -- 37. A New Take on Uptake: Dopamine Transporters & the Cellular Mechanisms of Amphetamine Action -- 38. A Retrospective on PET and the Amphetamine Paradigm: Validation and Paradoxes -- References -- 39. The Corelease of Glutamate by Dopamine Neurons -- 40. Psychostimulant-Induced Alterations of Monoaminergic Transporters: Implications for Neurotoxicity and Neuroprotection -- 41. Trace Amine Associated Receptor 1 is a Catecholamine Receptor that Differentially Controls DAT and NET Internalization -- 42. VGF-Derived Peptide TLQP-21: Structure, Function, and Biomedical Implications -- Acknowledgements -- References -- 43. Chromogranins the Key Proteins for the Storage and Regulation of Exocytosis in Chromaffin Cells -- 44. Chromogranin A in the Storage and Exocytosis of Catecholamines -- References -- 45. The Involvement of Vesicular ATP in the Storage and Exocytosis of Catecholamines of Bovine Chromaffin Cells -- References -- 46. The Role of Ca2+ Release from the Endoplasmic Reticulum in the Catecholamine Hypersecretion of Adrenal Chromaffin Cells from Spontaneously Hypertensive Rats -- 47. PACAP as a Primary Effector of the Acute Sympatho-Adrenal Stress Response -- 48. Amphetamine Induced Dopamine Release in Macaque Monkeys: Striking Differences Between Prefrontal Cortex and Caudate Nucleus -- 49. Attenuated Amphetamine-Induced Dopamine Release in Subjects at Ultra-High Risk for Substance Dependence.

50. The Membrane-Raft Protein Flotillin-1 is Essential in Dopamine Neurons for Amphetamine-Induced Behavior in Drosophila -- 51. Plant Flavonoids Affecting Adrenal Medullary Catecholamine Biosynthesis and Release -- 52. A Protein Complex for Dopamine Synthesis and Vesicular Storage: Target for Cellular Oxidative Damage -- 53. Overexpression of Parkin in The Nigrostriatal System Might Protect Dopaminergic Terminals From Methamphetamine Neurotoxicity Via Regulation of Dopamine Transporter -- 54. Increased Catecholamine Toxicity in Mice with Low Expression of VMAT2 -- THEME C: METABOLISM -- 55. Renalase: A New Player in Catecholamine Metabolism -- 56. Abnormal Monoamine Oxidase A VT in the Prefrontal and Anterior Cingulate Cortex During Major Depressive Episodes and High R... -- 57. CNS Catecholamine Metabolism - Emerging Concepts -- 58. Catestatin (Human Chromogranin A352-372) Induces Lipolysis and Fatty Acid Oxidation through Regulation of Adrenergic and Le... -- 59. Triple Deuteration Modifies Pharmacokinetics and Pharmacodynamics of Dopamine in PD Models -- 60. Understanding Catecholamine Metabolism as a Guide for Assessment of Sympathoadrenal Function and Dysfunction in Health and ... -- 61. Multiplex Immunoassay for Catecholamines -- 62. Modifiers of Neurofibromatosis-Associated Tumors and the Potential Role for Catecholamines and Sex Differences -- 63. Catecholamine Metabolism in Chromogranins Knock-Out Mice -- 64. Translation Research in Autism and Cancer: Novel Roles of MAO -- 65. COMT is a Major Contributor to Pain Perception: from Humans to Rats and Back to Humans -- 66. Novel COMT Inhibitors in Parkinson Disease -- 67. Effect of Opicapone, a New Catechol-O-Methyltransferase Inhibitor, in Levodopa Pharmakokinetics in the Cynomolgous Monkey -- Reference -- 68. Does Impaired Aldehyde Detoxification Play a Role in Parkinson's Disease?.

69. The Role of Aldehyde Detoxification in Parkinson's Disease -- 70. Pharmacological Profile of Opicapone in Wistar rat -- References -- THEME D: CATECHOLAMINE RECEPTORS AND CATECHOLAMINERGIC SIGNALING -- 71. How Drugs Bind and Control their Targets: Characterizing GPCR Signaling through Long-Timescale Simulation -- 72. Structural basis of Subtype Selectivity in Dopamine D3 and D2 Receptors -- References -- 73. Hormone-Mediated Activation of G Proteins by GPCRs: Insights from the Crystal Structure of a GPCR-G Protein Complex -- 74. Towards Better Understanding of G(s) Coupling in Catecholamine Receptors -- 75. Receptor Heteromerization: Understanding the Functional and Pathological Role of the Dopamine D4 Receptor -- 76. Trace Amines and Their Receptors: New Opportunities for Modulation of Brain Dopaminergic Functions -- 77. Cross-Talk between G Protein-Coupled Receptors: Challenges of Distinguishing Upstream from Downstream Mechanisms -- 78. Growth Hormone Secretagogue Receptor (GHSR1a, aka Ghrelin Receptor) is an Allosteric Modulator of Dopamine Signaling in the... -- 79. Regulation of β2Adrenergic Receptor Trafficking and Signaling by Ubiquitination and Deubiquitination -- 80. Sorting NEXIN-25 Interacts with D1 and D2Dopamine Receptors to Regulate Receptor Expression and Signaling -- 81. Trafficking of the D2 Dopamine Receptor Promotes Drug-Induced Changes in Neuronal and Behavioral Plasticity -- 82. D2 Receptors Control of Dopamine Levels -- 83. Integrated Approaches to Understand the Actions of GPCRs: The b-Arrestin-Dependent D2R Mediated Signaling Through Akt/GSK3 -- 84. Hyperdopaminergic Modulation of Inhibitory Transmission is Dependent on GSK-3β Signaling-Mediated Trafficking of GABAA Rece... -- 85. Simultaneous, Massively Parallel and Genome-Wide Interrogation of GPCR b-arrestin-ergic Signaling: Implications for GPCR Dr...

86. Backwards and Forwards with Molecular and Classical Pharmacology.