Arsenic in Drinking Water -- Copyright -- Other Reports of the Board on Environmental Studies and Toxicology -- Preface -- Contents -- Executive Summary -- THE CHARGE TO THE SUBCOMMITTEE -- THE SUBCOMMITTEE'S APPROACH TO ITS CHARGE -- THE SUBCOMMITTEE'S EVALUATION -- Health Effects -- Recommendations -- Disposition (Absorption, Distribution, Metabolism, and Excretion) -- Recommendations -- Mechanism or Mode of Action -- Recommendations -- Variation in Human Sensitivity -- Recommendations -- Other Considerations -- Recommendations -- RISK CHARACTERIZATION -- Recommendations -- 1 Introduction -- BACKGROUND -- SCIENTIFIC CONTROVERSIES -- ORGANIZATION OF THIS REPORT -- REFERENCES -- 2 The U.S. Environmental Protection Agency's 1988 Risk Assessment for Arsenic -- OVERVIEW OF THE EPA 1988 SPECIAL REPORT -- Hazard Identification -- Dose-Response Assessment -- Nutritional Essentiality -- EPA'S 1988 RISK ASSESSMENT: 10 YEARS LATER -- Data Limitations -- Estimating Risk in the United States -- SUMMARY -- REFERENCES -- 3 Chemistry and Analysis of Arsenic Species in Water, Food, Urine, Blood, Hair, and Nails -- SUMMARY OF ARSENIC COMPOUNDS IN WATER AND FOOD -- RELEVANT CHEMICAL CONSIDERATIONS -- Is Arsenic Similar to Phosphorus? -- Affinity Of Arsenic For Sulfur -- Biomethylation of Arsenic -- Some Geo-chemical Considerations: Absorption and Redox -- Microbial Activity and Arsenic Mobilization -- Free Radical and Peroxy Species -- ANALYSIS OF ARSENIC COMPOUNDS -- Hydride Generation with Speciation -- Hidden Arsenic Species -- Arsenic(III) Species -- Chromatographic Separation of Involatile Arsenic Species -- Mass Spectrometry for Arsenic Speciation -- ARSENIC IN WATER -- Arsenic in Groundwater -- Arsenic in Fresh Surface Water -- Arsenic in Estuarine Water -- Practical Quantification Level for Arsenic in Drinking Water -- ARSENIC IN FOOD.

Total-Arsenic Concentrations -- Studies of Arsenic Speciation in Food -- Higher-Level Speciation Studies of Food -- The Nature of Arsenic in Plants -- ARSENIC IN URINE, BLOOD, HAIR, AND NAILS -- Arsenic in Urine -- Total Arsenic in Urine -- Arsenic Species in Urine -- Collection and Storage of Urine Samples for Arsenic Speciation Analysis -- Arsenic Species in Blood -- Arsenic in Hair and Fingernails -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 4 Health Effects of Arsenic -- CANCER EFFECTS -- Ecological Studies -- Cohort Studies -- Case-Control Studies -- Occupational Studies -- NONCANCER EFFECTS -- Cutaneous Effects -- Gastrointestinal Effects -- Cardiovascular Effects -- Hematological Effects -- Pulmonary Effects -- Immunological Effects -- Neurological Effects -- Endocrinological Effects -- Reproductive and Developmental Effects -- Epidemiological Associations -- Animal Data -- Placental Transfer -- Pathogenesis and Possible Mechanisms of Teratogenesis -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 5 Disposition of Inorganic Arsenic -- ABSORPTION -- BIOTRANSFORMATION -- Arsenate Reduction and Arsenite Methylation -- Species Differences -- Factors Influencing the Metabolism of Arsenic -- TRANSPORTATION, DISTRIBUTION, AND ELIMINATION -- Transportation in Blood -- Tissue Distribution -- Intracellular Distribution -- Elimination -- KINETIC MODEL -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 6 Biomarkers of Arsenic Exposure -- ARSENIC IN URINE -- ARSENIC IN BLOOD -- ARSENIC IN HAIR AND NAILS -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 7 Mechanisms of Toxicity -- CANCER EFFECTS -- Results from Bioassays -- Inorganic Arsenic -- Monomethylarsonic Acid (MMA) -- Dimethylarsinic Acid (DMA) -- Relevance of Findings of Bioassays to Humans -- Mode of Action.

Genotoxic Effects Induced by Arsenic Compounds -- Mutational Spectrum -- Comutagenicity -- DNA Methylation -- Oxidative Stress -- Cell Proliferation -- Arsenic-Induced Carcinogenicity and the Shape of Dose-Response Curve-A Mode-of-Action Approach -- NONCANCER EFFECTS -- Inhibitory Effects on Cellular Respiration -- Alterations in the Heme and Porphyrin Biosynthetic Pathways -- Alterations in Cellular Gene Expression-Stress Protein Induction -- Arsenic Toxicity and Metallothionein -- Arsine Gas Toxicity -- Interactions Between Arsenic and Other Common Toxic Metals -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 8 Variation in Human Sensitivity -- VARIATION IN ARSENIC METABOLISM -- Methodological Aspects -- Genetic Polymorphism -- Age, Sex, and Recreational Habits -- Effect of Dose -- Interindividual Variation -- NUTRITIONAL STATUS -- Methyl Group Donors -- Selenium -- Zinc -- Nutritional Status of Populations in Taiwan -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 9 Essentiality and Therapeutic Uses -- DEFINITION OF ESSENTIALITY -- EVIDENCE FOR ESSENTIALITY -- Physiological Importance -- Essentiality in Humans -- Goats and Minipigs -- Rats -- Chicks -- Data Consistency and Reproducibility -- Biochemical Mechanism of Action -- Dose Aspects -- THERAPEUTIC USES OF ARSENIC -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 10 Statistical Issues -- A REVIEW OF DOSE-RESPONSE MODELING AND RISK ASSESSMENT -- THE EPA 1988 ANALYSIS -- Sources of Uncertainty in the EPA 1988 Analysis -- PROBLEMS WITH RISK ASSESSMENT BASED ON ECOLOGICAL DATA -- INTERNAL-CANCER DATA FROM TAIWAN -- OTHER ISSUES -- DISCUSSION -- SUMMARY AND CONCLUSIONS -- RECOMMENDATIONS -- REFERENCES -- 11 Risk Characterization -- REFERENCES -- Addendum to Chapter 9 Experimental Conditions for Nutritional Studies with Arsenic -- RATS AND CHICKS.

Goats and Minipigs -- REFERENCES -- Addendum to Chapter 10 Table A10-1 Internal Cancer Data From Arsenic-exposure Studies Conducted Taiwan Region Endemic To... -- References.