Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Title:
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Author:
Chen, Chun Chieh
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (552 seconds)
Series:
Bioengineering
General Note:
Title from resource description page
Abstract:
We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/57020