Genetically Yours : Bioinforming, Biopharming and Biofarming.
Title:
Genetically Yours : Bioinforming, Biopharming and Biofarming.
Author:
Lim, Hwa A.
ISBN:
9789812777539
Personal Author:
Physical Description:
1 online resource (440 pages)
Contents:
CONTENTS -- Preface -- Chapter 1 The Genome Project: Its Impacts and Implications -- 1 Looking Back In The Future -- 2 Lewis-Clark De Javu -- 3 The Human Genome Tour -- 4 Historical Perspective - The Timeline Of The Human Genome Project -- 4.1 Pre-genomic Sequencing Cottage Industry -- 4.2 Scaling up a la Big Science - A Biological Moonshot A Biological Particle Smasher -- 4.3 Enters the Black Knight -- 4.4 Divide-and-Conquer Strategy -- 4.5 Shotgun Strategy -- 4.6 The Traveling Salesman Is a Chinese Postman -- 4.7 The Race to the Finishing Line - Bigger is Better -- 4.8 Complementary Strategies - Ally or Foe -- 4.9 From Genome Marathon to Sprint to the Finishing Line -- 4.10 The Gutenberg Press of the Human Genome Project -- 5 A Small Step For Genome A Giant Step For Humankind -- 5.1 Impacts and Implications - Deciphering the Rosetta Tablet -- 5.1.1 Genetic Engineering -- 5.1.2 Humpty Dumpty -- 5.1.3 Single Nucleotide Polymorphism -- 5.1.4 Patentability of Biocommons -- 5.1.5 Ethical Social and Legal Issues -- 6 What Is In Store? -- 6.1 Gaps Filling -- 6.2 Gene Finding -- 6.3 Other Genomes -- 6.4 Gene Function -- 6.5 Single Nucleotide Polymorphisms -- 6.6 The Eclectic Bioinformatics -- 6.7 An Array of Possibilities - New Genomic Technologies -- 7 The Next Fifty Years -- 8 The Test Of Time -- Chapter 2 Post-Genomics Matters: Send out A Thousand Ships Not Catalogue a Thousand Genes -- 1 Genome Armada -- 2 Perplexity And Enlightenment -- 2.1 The New Genetic Math - 1.5 X Caenorhabditis elegans = Homo sapiens -- 2.2 Human Genome Archaeology -- 2.3 The Genome Topography -- 3 How The Statistics Stack Up? -- 3.1 On the Pessimistic Side -- 3.2 On the Mixed Side -- 3.3 On the Positive and Opportunistic Side -- 3.4 Comparatively Speaking -- 4 Genestimate Discrepancies -- 4.1 Humbled by Our Own Ego Genes.
5 Genome - A Map To Profitability? -- 5.1 Biotech Bay Biotech Beach Biotech Beltway Biotech Corridor -- 5.2 Biotechnology Tools: Friends or Foes? -- 6 The Other Sequencing Centers -- 7 From The Book Of Life To Inventory Of Life -- Chapter 3 AgBiotechnology: Genetically Modified -- 1 The Biotech Revolution -- 2 Mother Nature Father Time and Author Children -- 3 From Green Revolution To AgBiotech Revolution -- 3.1 Genetically Modified Crops -- 3.1.1 Yield Increase via Genetics -- 3.1.2 Genetically Fortified Crops - Golden Rice -- 3.1.3 Plant Antibody Factory -- 3.1.4 Petro Alternatives -- 3.2 Genetically Modified Trees -- 3.3 Genetically Engineered Animals -- 3.4 Genetically Modified Microbes -- 3.5 Germ Warfare Agents -- 4 Biotech Backlash -- 5 StarLink For Hogs Not Humans -- 5.1 FDA Snafu -- 5.2 Bt Not for Butterflies -- 5.3 Corn Dogs -- 5.4 The Extent of Commingling -- 6 Organic Food -- 6.1 Long Term Ramifications -- 6.2 From Taco to Genes -- 6.3 Warranty of Edibility -- Chapter 4: Aqua Biotechnology -- 1 The Fish Tale -- 2 Need For Aquaculture -- 2.1 Gene Transfer Protocol in Fish -- 2.2 Fish As Medical Tools -- 2.2.1 Knock Out The Fish That Roars -- 2.2.2 Zebrafish in Development Studies -- 2.2.3 The Zebrafish - Closer to Heart than You Know -- 2.3 The Rule of the Game - Growth Enhancement -- 2.4 Antifreeze -- 2.5 Disease Resistance -- 3 Gene Transfer In Fish -- 4 Transgenic Fish -- 4.1 Carp - Food and See Food -- 4.1.1 Genetically Modified Carp -- 4.1.2 Safety Considerations of Transgenic Carp for Human Consumption -- 4.1.3 Environmental Safety - Gene Flow -- 4.1.4 No Carping with Carp - Natural Gene Flow -- 4.2 The Tale of Catfish - Transgenic Creole -- 4.3 Salmon for Sushi -- 4.4 Shrimps -- 5 The Prospect Of Transgenic Fish -- 6 Other Fish To Fry -- Chapter 5 Clonology and Clonetechnology -- 1 The Genetic Age -- 2 Clonolgy.
2.1 Parthenogenesis - Virgin Birth -- 2.2 Photocopying Life Forms -- 2.3 Win a Clone at the Diary Expo -- 3 Clonetechnology -- 3.1 The Celebrated Dolly -- 3.1.1 Adult Cell Reprogramming -- 3.2 Monkeying with Nature -- 3.3 Sheep Factory -- 3.4 Dolly Polly and "Holly" Calf -- 3.5 Got Milk? Goat Milk -- 3.6 Second Chance - Clone of the Oldest Bull -- 3.7 Artificial Monkey Twins -- 3.8 Inserted DNA and ANDi -- 3.9 Clone of a Clone - More Bulls -- 3.10 Five Piglets: Oink! Oink! Oink! Oink! Oink! - Organs for Sale -- 3.11 Spring Holy Cows -- 3.11.1 Telomerase - A Vignette of the Fountain of Youth -- 3.12 Xena - No Warrior Princess but a Piglet -- 3.13 Cow Pregnant with Clone - Jurassic Amusement Park -- 4 No Jurassic Amusement Yet -- Chapter 6 Pet Cloning And BioFactory -- 1 Attempts At Cloning -- 1.1 Cell Specialization -- 1.2 Embryo Splitting -- 1.3 Gaps in Cell Cycle -- 2 Cloning Techniques -- 2.1 Embryo Splitting Technique -- 2.2 The Nuclear Transfer Technique -- 2.2.1 The Roslin Technique -- 2.2.2 The Honolulu Technique -- 3 From Barnyard To PerPETually Yours -- 3.1 K-9 Cloning -- 3.2 Feline the Copy Cat -- 4 Which Comes First? The Chicken Or The Egg? -- 5 White Elephant -- 6 A Mammoth Undertaking -- 7 Animal Factory - From Fanning To Pharming -- 7.1 Animal Bioreactors -- 7.1.1 Antimicrobial Peptides -- 7.1.2 Transgenic Technology Development -- 7.1.3 Heterologous Protein Production -- 7.1.4 Collecting and Purifying Product -- 7.2 Key Transgenic Players and Future Trends -- 7.3 Barnyard Organ and Tissue Shops -- 7.3.1 Organ Supply and Demand -- 7.3.2 Strides in Xenotransplant -- 7.4 Barnyard Teats as Spinnerets - Silk in Milk -- 8 Ethical Issues And Regulatory Compliance -- Chapter 7 Human Cloning And Stem Cell Research -- 1 Human Cloning To Be Or Not To Be? -- 2 Politics Of Cloning.
3 To Be Or Not To Be That Is The Question -- 3.1 The Good - Medical Applications -- 3.2 The Bad - Clandestine Efforts -- 3.3 The Ugly - Cloning Misconceptions -- 4 Louis Brown Of Cloning -- 4.1 Infertile Parents -- 4.2 Carriers of Defective Genes -- 5 Issues -- 5.1 The Question of Identity - Like Father Like Son -- 5.2 Silver Linings -- 5.3 The Dark Cloud - All Is Fine Unless You Are The Clone -- 5.3.1 Current State of the Art of Cloning -- 5.3.2 Preliminary Evidence of Awry Clone - Problems with Reprogramming -- 6 Dream Things That Never Were -- 7 The Law -- 7.1 The Genie Is Out of the Bottle into The Brave New World -- 8 Message In A Bottle From The Future -- 9 Sherlock Holmes - The Clone Murder Detective -- 10 Stem Cell Research -- 10.1 Stem Cell 101 -- 10.2 Derivation of Stem Cells -- 10.3 Sources of Embryos -- 10.4 Applications of Stem Cell Research -- 10.5 From Degenerative Disorders to Regenerative Medicines -- 10.6 Embryonic Stem Cells versus Adult Stem Cells -- 10.7 Federal Support -- 11 Private Companies In Stem Cell Business -- 12 Reactions To Bush's Decision -- 13 What Next? -- 14 Hotbed For Stem Cell Research - University Of Wisconsin -- 14.1 6 200 806 -- 14.2 6 200 806 Reasons to Worry About -- 15 Hot Off The Press -- Chapter 8 Genomic And Proteomic Technologies And Beyond -- 1 Biochip -- 2 The DNA Chip Technology -- 2.1 The DNA Chip Array -- 2.2 Formats -- 2.3 Applications of DNA Microarray Technology -- 2.3.1 Functional Genomics Research -- 2.3.2 Disease Diagnosis -- 2.3.3 Sequencing and Gene Discovery -- 2.3.4 Drug Discovery -- 2.3.5 Toxicogenomics and Pharmacogenomics -- 2.3.6 Environmental Studies -- 2.3.7 Agricultural Science -- 3 Biochip Market -- 3.1 Market Segments -- 4 Microchip But Macro Impacts -- 4.1 A Chip off the Old Block -- 5 Future Outlook -- 5.1 Challenges -- 5.2 Future Development.
6 Crossing The Chasm From Genomics To Proteomics -- 6.1 The Cell DNA and Protein Synthesis -- 6.2 Proteomics - Direct Impact on Drug Discovery -- 6.2.1 Reducing Drug Toxicity -- 6.2.2 Diagnosing Disease -- 6.2.3 Increasing Throughput of Drug Discovery -- 6.3 Turning Discovery Into Cure -- 7 Automation Of Proteomics -- 8 Picks And Shovels Of Proteomics -- 8.1 2D Gel Electrophoresis -- 8.2 Classification by Absorption -- 8.3 Emerging Approaches -- 9 Promise Of Antibody Microarray -- 10 Two Useful Twists In The Protein Junkyard -- 11 Paleontology Of Diseases - Beyond Genomics And Proteomics -- 12 Omics This And Omics That -- 13 Directed Evolution -- Chapter 9 Submicron Technology And Nanotechnology -- 1 Midas! Gold In Potentia -- 2 From Alchemy To Algeny -- 3 Now Nanotechnology -- 3.1 Nano Research And Development -- 3.2 Self Assembly Versus Positional Assembly -- 3.3 Nature's Assembler -- 3.4 The Diamond of Living System - Stem Cell -- 3.5 A Caveat in Mimicking Nature -- 3.6 Drexler's Assemblers -- 3.7 Manipulations In Nanoscale -- 4 From Controlled Environment To Work Environment -- 5 From Algeny To Almoly -- 6 Biomimetics - The Confluence Of Biotechnology And Nanotechnology -- 7 Nano Dragon -- Chapter 10 Patentability in Biotechnology -- 1 Decoding A Genetic Announcement -- 2 Enclosing The Genetic Commons -- 2.1 Europe -- 2.1.1 Tudor England -- 2.1.2 Medieval Europe -- 2.1.3 Social Impact of Land Enclosure -- 2.1.4 Other Enclosures: Land Sea Air and the Invisible -- 2.2 The Middle Kingdom -- 2.2.1 West Meets East -- 2.2.2 Maritime Expeditions -- 2.2.3 East Meets West -- 2.3 The New World - USA -- 2.3.1 Opening of the Genetic Floodgate -- 2.3.2 Impacts of the Supreme Court's Decision -- 3 The Final Frontier - Where No Life Scientists Have Gone Before -- 3.1 Biopatentability -- 4 Biopiracy And Biocolonialism.
4.1 Cash Cows from Crops.
Abstract:
Written by a pioneer and authority, this invaluable book covers all the key aspects and current affairs in the field of biotechnology, with topics ranging from genome projects, through animal and human cloning, to biowarfare. As an academic-turned-entrepreneur, the author is at ease in providing vivid firsthand accounts from both the scientific and the business perspective. This book is addressed primarily to experts and professionals who are very busy but who wish to gain insights through a different and comprehensive perspective of this important field. It is also aimed at laypeople who are interested in learning more about bioinformatics, and the biotechnology, pharmaceutical, and healthcare industries. The book is also ideal as an easy-to-read supplementary reference in classrooms. Each chapter is self-contained and footnotes provide further references for interested readers. Sample Chapter(s). Chapter 1.1: Looking Back in the Future (71 KB). Chapter 1.2: Lewis-Clark Dé Jàvu (71 KB). Chapter 1.3: The Human Genome Tour (54 KB). Chapter 1.4: Historical Perspective - The Timeline of the Human Genome Project (94 KB). Chapter 1.5: A Small Step for Genome, A Giant Step for Humankind (69 KB). Chapter 1.6: What is in Store (59 KB). Chapter 1.7: The Next Fifty Years (152 KB). Chapter 1.8: The Test of Time (225 KB). Contents: The Genome Project: Its Impacts and Implications; Post-Genomics Matters: Send Out a Thousand Ships, Not Catalogue a Thousand Genes; AgBiotechnology: Genetically Modified; Aqua Biotechnology; Clonology and Clonetechnology; Pet Cloning and BioFactory; Human Cloning and Stem Cell Research; Genomic and Proteomic Technologies and Beyond; Submicron Technology and Nanotechnology; Patentability in Biotechnology; Biological and Biology-Related Information as a Commodity and the Rise of Bioinformatics; Turbo-Charging Bioinformation for Drug
Discovery; A New Kind of War: Biowarfare and Info Warfare; Two Decades of Biotechnology and a Decade of Bioinformatics. Readership: Researchers in biotechnology, bioinformatics, genetics, fish and marine biology; workers in the pharmaceutical and healthcare industries; lay people.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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