A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Title:
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Author:
Wang, Xiaoliang
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (472 seconds)
Series:
Biology
General Note:
Title from resource description page
Abstract:
This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/55825