Cover -- Copyright -- Dedication -- Editors -- Foreword to the First Edition -- Preface -- Contents -- Section I Strategies for the Use of Agents at High Dose -- 1 Pharmacologic Strategies for High-Dose Therapy -- 2 Preclinical Models for High-Dose Therapy -- 3 Pharmacokinetics -- 4 What Is the Best Strategy for Autologous Hematopoietic Stem Cell Transplantation in Cancer -- 5 Strategies for the Use of Total-body Irradiation as Systemic Therapy in Hematologic Malignancies -- 6 Radioimmunotherapy -- 7 Immune Adjuvant Therapy Post High-Dose Therapy -- 8 A Health Policy Perspective on High-Dose Cancer Therapy: Cost, Effectiveness, and Cost-Effectiveness -- 9 Quality of Life after Bone Marrow Transplantation -- 10 Gene Therapy -- Section II Reestablishing Hematopoiesis after Dose-Intensive Therapy Transplantation -- 11 The Hematopoietic Microenvironment -- 12 Hematologic Reconstitution after Allogeneic Hematopoietic Cell Transplantation -- 13 Allogeneic Cord Blood Hematopoietic Stem Cells Transplants in Malignancies -- 14 Bone Marrow Transplantation Using Unrelated Donors -- 15 Autologous Bone Marrow Transplantation -- 16 Reestablishing Hematopoiesis with Peripheral Stem Cells -- 17 Immunologic Reconstitution after High-Dose Chemoradiotherapy and Allogeneic or Autologous Bone Marrow or Peripheral Blood Hematopoietic Stem Cell Transplantation -- Marrow Contamination -- 18 Minimal Disease: Detection and Significance -- 19 Negative and Positive Stem Cell Selection -- 20 Stem Cell In Vitro Purging for Autologous Transplantation -- Growth Factors -- 21 Granulocyte-Macrophage Colony-Stimulating Factor -- 22 Recombinant Human Granulocyte Colony-Stimulating Factor Support of the Cancer Patient -- 23 Erythropoietin -- 24 The Biology and Clinical Use of Stem Cell Factor -- 25 Other Cytokines (IL-11, Thrombopoietin, flt-3 Ligand, and IL-3).

Section III Laboratory and Clinical Support for Dose-Intensive Therapy -- 26 The American Society of Clinical Oncology and American Society of Hematology Recommended Criteria for the Performance of Bone Marrow Transplantation -- 27 Nursing for Patients Receiving High-Dose Chemotherapy with Hematopoietic Rescue -- 28 Line Maintenance -- 29 Blood Bank Support for Patients Undergoing High-Dose Chemotherapy -- 30 Infectious Complications after High-Dose Chemotherapy -- 31 Pulmonary Complications -- 32 Hepatic Complications of Bone Marrow Transplantation -- 33 Cardiovascular System and High-Dose Therapy -- 34 Multiple Organ Dysfunction Syndrome -- 35 Dermatology -- 36 Genitourinary, Gastrointestinal, Endocrine, Nervous System, and Coagulation Complications -- 37 Gonadal Complications -- Section IV Clinical Applications of High-Dose Therapy -- 38 High-Dose Therapy in Acute Myeloid Leukemia -- 39 High-Dose Therapy in Acute Lymphoblastic Leukemia -- 40 Chronic Myelogenous Leukemia -- 41 Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia -- 42 High-Dose Therapy in Multiple Myeloma -- 43 High-Dose Therapy for Hodgkin's Disease -- 44 High-Dose Therapy for the Treatment of Non-Hodgkin's Lymphoma -- 45 High-Dose Therapy in Burkitt's Lymphoma -- 46 High-Dose Chemotherapy in Patients with Germ Cell Cancer -- 47 Dose-Intensive Therapy for Breast Cancer -- 48 Lung Cancer -- 49 High-Dose Chemotherapy and Stem Cell Transplantation for Ovarian Cancer -- 50 High-Dose Therapy and Stem Cell Transplantation for Neuroblastoma and Other Pediatric Solid Tumors -- 51 Brain Tumors -- 52 Other Solid Tumors -- Color Figures -- Subject Index.