CELL PROLIFERATION: PROCESSES, REGULATION AND DISORDERS -- CELL PROLIFERATION: PROCESSES, REGULATION AND DISORDERS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter I: Glutamate and its Receptors in Controlling Proliferation of Oligodendrocyte Progenitor Cells -- Abstract -- 1. Introduction -- 2. OPCs Represent the Largest Pool of Proliferating Cells in the Brain -- 3. Glutamate Receptors on Oligodendroglial Progenitors and their Role during Cell Proliferation in Culture -- 4. Glutamatergic Synapses on Oligodendroglial Progenitors and their Possible Role during Proliferation -- 4.1. OPCs Receive Functional Synaptic Input from Neurons -- 4.2. Morphology of OPCs during Mitosis -- 4.3. Neuron-glial Synapses during Mitosis -- 4.4. Are Neuron-glia Synapses Involved in Regulation of OPC Proliferation? -- 5. Proliferation of Oligodendroglial Progenitors In Vivo and its Modulation by Electrical Activity in Axons -- 5.1. Neuronal Activity Controls Proliferation of Oligodendroglial Progenitors In Vivo -- 5.2. How do Electrically Active Axons Signal to Glial Cells to Divide? -- Conclusion -- Acknowledgments -- References -- Chapter II: The Two Faces of TGF-ß in Breast Cancer: Tumour Suppressor and Tumour Promoter -- Abstract -- List of Abbreviations -- 1. Introduction of the TGF-ß Superfamily -- 2. The Mechanism of TGF-ß Signal Transduction -- 2.1. The TGF-β Pathway -- 2.2. Non-Smad Signalling -- 2.3. Regulation of the TGF-β-Induced Smad Pathway -- 3. The Dual Role of TGF-ß in Breast Cancer -- 3.1. Inhibition of Tumourigenesis -- 3.2. Promotion of Tumour Progression -- 3.3. EMT -- 3.4. From Primary Site to Circulation -- 3.5. Targeting Specific Organs -- Conclusion -- Acknowledgments -- References -- Chapter III: MicroRNAs and Their Therapeutic Potential for Vascular Smooth Muscle Cell Proliferation in Restenosis.

Abstract -- 1. Introduction -- 2. SMC Proliferation in Restenosis -- 3. MiRNAs in SMC Proliferation -- 3.1. miR-143 and miR-145 -- 3.2. miR-221 and miR-222 -- 3.3. miR-1 and miR-133 -- 3.4. miR-21 -- 3.5. miR-26a -- 3.6. miR-208a -- 3.7. let-7d -- 4. MiRNAs in Cell Cycle -- Conclusion -- References -- Chapter IV: Impaired Proliferation as a Component of the Pathogenesis of Follicular Persistence Associated with Cystic Ovarian Disease -- Abstract -- 1. Introduction -- 2. Regulation of the Cell Cycle in the Ovary -- 3. Ovarian Cysts -- 4. Altered Proliferation in Follicular Cysts -- 5. Decreased Apoptosis Contributes to Follicular Persistence -- Conclusion -- References -- Chapter V: Extracellular Protein-Induced Plant Cell Proliferation -- Abstract -- 1. Introduction -- 2. Cell Systems to Investigate Cell Proliferation -- 3. Conditioned Medium Enhances Cell Division during Somatic Embryogenesis -- 4. Chitinases/PR Proteins Involvement in Cell Proliferation -- 5. AGP-mediated Promotion of Cell Proliferation -- 6. Other Extracellular Proteins Identified during Proliferation -- 7. Cell Proliferation versus Cell Differentiation -- 8. Other Related Aspects of Cell Proliferation Control -- Growth Regulators Coordinate Proliferation of Plant Cells -- Cryopreservation Enhances Cell Proliferation -- Molecular Regulation of Cell Proliferation and Differentiation -- Conclusion and Future Outlooks -- Acknowledgments -- References -- Chapter VI: Cell Proliferation in Drug Discovery and Development -- Abstract -- 1. Introduction -- 2. The Application of MTS Colorimetric Assay for Measurement of Cell Proliferation and Cytotoxicity -- 2.1. MTS Colorimetric Assay Introduction -- 2.2. Cytokines and Cell Proliferation -- 2.3. Immunotoxins and Cell Proliferation -- 2.4. Targeted Cell-Selective Cytolysis and Gene Therapy -- 3. Real-time Dynamic Cell Growth Monitoring.

3.1. Real-time Cell Electronic Sensing (RT-CES) -- 3.2. RT-CES Application for Cytoxicity of Immunotoxins -- 3.3. RT-CES and Selective Cytolysis with Tropism-modified Adenoviral Vectors -- 4. Signal Transduction and Cell Proliferation (Reporter Gene Assays) -- 4.1. STAT3 Luciferase Reporter Gene Assay -- Conclusion -- Acknowledgments -- References -- Chapter VII: Cell Adhesion and Proliferation on Polymeric Biomaterials for Tissue Engineering -- Abstract -- 1. Introduction -- 1.1. The history of Biomaterial Development -- 1.2. Parameters for Biomaterial Research -- 1.3. The Advantage of Synthetic Polymeric Biomaterials -- 2. The Synthesis of Polymeric Biomaterials and the Effects on Cell Adhesion and Proliferation -- 2.1. The Design of Polymer Molecular Structure -- 2.2. The Incorporating of Bioactive Molecules -- 3. The Surface Modification of Polymeric Biomaterials and the Effect on Cell Adhesion and Proliferation -- 3.1. Surface Topographical Strategy and Its Application -- 3.2. Surface Chemical Strategy and Its Application -- 4. The Bulk Modification of Polymeric Biomaterials and the Effect on Cell Adhesion and Proliferation -- 4.1. Composites and Their Application in Bone Tissue Engineering -- 4.2. Bulk Modification with Bioactive Molecules -- 5. The Geometry of 3D Scaffolds and the Effect on Cell Adhesion and Proliferation in Bone Tissue Engineering -- 5.1. Porosity and PoreSize -- 5.2. Interconnected Channels -- Conclusion -- References -- Index.