Cover image for Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Title:
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Author:
Drisko, Cody R.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (315 seconds)
Series:
Chemistry
General Note:
Title from resource description page
Abstract:
Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/58508
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