FrontMatter -- Reviewers -- Contents -- Table, Figure, and Boxes -- Acronyms -- 1 Introduction -- 2 Framing the Problem -- 3 Recruitment Challenges in Clinical Trials for Different Diseases and Conditions -- 4 Models for Public Engagement -- 5 Messages and Methods for Public Engagement -- 6 The Media -- 7 Novel Clinical Trial Designs -- 8 The Health System's Structure and Culture -- 9 Toward a Patient-Centered Strategy for Clinical Trials -- References -- Appendix A: Workshop Agenda -- Appendix B: The Clinical Trials Process -- Appendix C: Participant Biographies.