The AH Receptor in Biology and Toxicology -- CONTENTS -- PREFACE -- CONTRIBUTORS -- PART I: HISTORICAL BACKGROUND -- 1 History of Research on the AHR -- PART II: AHR AS A LIGAND-ACTIVATED TRANSCRIPTION FACTOR -- 2 Overview of AHR Functional Domains and the Classical AHR Signaling Pathway: Induction of Drug Metabolizing Enzymes -- 3 Role of Chaperone Proteins in AHR Function -- 4 AHR Ligands: Promiscuity in Binding and Diversity in Response -- 5 Dioxin Response Elements and Regulation of Gene Transcription -- 6 The AHR/ARNT Dimer and Transcriptional Coactivators -- 7 Regulation of AHR Activity by the AHR Repressor (AHRR) -- 8 Influence of HIF1α and Nrf2 Signaling on AHR-Mediated Gene Expression, Toxicity, and Biological Functions -- 9 Functional Interactions of AHR with Other Receptors -- 10 The E3 Ubiquitin Ligase Activity of Transcription Factor AHR Permits Nongenomic Regulation of Biological Pathways -- 11 Epigenetic Mechanisms in AHR Function -- PART III: AHR AS A MEDIATOR OF XENOBIOTIC TOXICITIES: DIOXINS AS A KEY EXAMPLE -- 12 Role of the AHR and its Structure in TCDD Toxicity -- 13 Nongenomic Route of Action of TCDD: Identity, Characteristics, and Toxicological Significance -- 14 Interspecies Heterogeneity in the Hepatic Transcriptomic Response to AHR Activation by Dioxin -- 15 Dioxin-activated AHR: Toxic Responses and the Induction of Oxidative Stress -- 16 Dioxin Activated AHR and Cancer in Laboratory Animals -- 17 Teratogenic Impact of Dioxin Activated AHR in Laboratory Animals -- 18 The Developmental Toxicity of Dioxin to the Developing Male Reproductive System in the Rat: Relevance of the AHR for Risk Assessment -- 19 TCDD, AHR, and Immune Regulation -- 20 Effects of Dioxins on Teeth and Bone: The Role of AHR -- 21 Impacts of Dioxin-Activated AHR Signaling in Fish and Birds.

22 Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans -- 23 The Toxic Equivalency Principle and its Application in Dioxin Risk Assessment -- 24 AHR-active Compounds in the Human Diet -- 25 Modulation of AHR Function by Heavy Metals and Disease States -- 26 Transgenic Mice with a Constitutively Active AHR: A Model for Human Exposure to Dioxin and Other AHR Ligands -- PART IV: AHR AS A PHYSIOLOGICAL REGULATOR -- 27 Structural and Functional Diversification of AHRs During Metazoan Evolution -- 28 Invertebrate AHR Homologs: Ancestral Functions in Sensory Systems -- 29 Role of AHR in the Development of the Liver and Blood Vessels -- 30 Involvement of the AHR in Cardiac Function and Regulation of Blood Pressure -- 31 Involvement of the AHR in Development and Functioning of the Female and Male Reproductive Systems -- 32 The AHR in the Control of Cell Cycle and Apoptosis -- 33 The AHR Regulates Cell Adhesion and Migration by Interacting with Oncogene and Growth Factor-Dependent Signaling -- 34 The Physiological Role of AHR in the Mouse Immune System -- 35 AHR and the Circadian Clock -- INDEX -- COLOUR PLATES.