Cover -- Title Page -- Copyright -- CONTENTS -- FOREWORD -- PREFACE -- CONTRIBUTORS -- PART I INTRODUCTION -- 1 FUNDAMENTALS OF DRUG DELIVERY -- 1.1 Introduction: History and Future of Drug Delivery -- 1.2 Terminology -- 1.3 Basic Pharmacokinetics -- 1.4 Basic Pharmacodynamics -- 1.5 Mass Transfer -- 1.6 Key Points -- 1.7 Homework Problems -- 2 CHALLENGES OF DRUG DELIVERY -- 2.1 Introduction -- 2.2 History and Challenges of Drug Delivery -- 2.3 Physical Barriers -- 2.4 Metabolic and Chemical Concerns -- 2.5 Physical Properties of Therapeutics -- 2.6 Polymer Carriers as a Solution to Challenges -- 2.7 Key Points -- 2.8 Homework Problems -- PART II INJECTABLE POLYMERIC DRUG DELIVERY SYSTEMS -- 3 POLYMER-DRUG CONJUGATES -- 3.1 Introduction -- 3.2 Historical Perspective -- 3.3 Polymer-Drug Conjugates: Biological Rationale -- 3.4 Structural Features of Polymer-Drug Conjugates -- 3.5 Making a Polymer-Drug Conjugate -- 3.6 Current Challenges and Future Perspectives -- 3.7 Key Points -- 3.8 Worked Example -- 3.9 Homework Problems -- 4 POLYMERIC MICROPARTICLES -- 4.1 Introduction -- 4.2 The Rationale for Microparticles -- 4.3 Defining the Design Criteria -- 4.4 Polymer Selection -- 4.5 Microparticle Synthesis -- 4.6 Microparticle Characterization Methods -- 4.7 Drug Release from Microparticles -- 4.8 Microparticle Design Examples -- 4.9 Key Points -- 4.10 Worked Example -- 4.11 Homework Problems -- 5 POLYMERIC NANOPARTICLES -- 5.1 Introduction -- 5.2 PNP Design -- 5.3 PNP Formulation Methods and Targeting -- 5.4 Nanoparticle Targeting Overview -- 5.5 PNP Characterization -- 5.6 Major Clinical Achievements -- 5.7 Key Points -- 5.8 Worked Example -- 5.9 Homework Problems -- 6 BLOCK COPOLYMER MICELLES AND VESICLES FOR DRUG DELIVERY -- 6.1 Introduction -- 6.2 Drug Encapsulation and Release -- 6.3 Bioavailability and Biodistribution.

6.4 Stimuli Responsiveness -- 6.5 The Immune System -- 6.6 Gene Therapy -- 6.7 Cancer Therapy -- 6.8 Conclusions -- 6.9 Key Points -- 6.10 Homework Problems -- PART III IMPLANTABLE POLYMERIC DRUG DELIVERY SYSTEMS -- 7 IMPLANTABLE DRUG DELIVERY SYSTEMS -- 7.1 Introduction -- 7.2 Nondegradable Polymeric Implants -- 7.3 Biodegradable Polymeric Implants -- 7.4 Conclusions and Future Perspectives -- 7.5 Key Points -- 7.6 Homework Problems -- 8 POLYMERIC DRUG DELIVERY SYSTEMS IN TISSUE ENGINEERING -- 8.1 Introduction -- 8.2 Wound Healing as a Prototype for Adult Tissue Generation -- 8.3 Bioactive Factors in Tissue Engineering and Regenerative Medicine -- 8.4 Delivery of Growth Factors in Tissue Engineering and Regenerative Medicine -- 8.5 Key Points -- 8.6 Worked Example -- 8.7 Homework Problems -- PART IV ORAL POLYMERIC DRUG DELIVERY SYSTEMS -- 9 ORAL CONTROLLED-RELEASE POLYMERIC DRUG DELIVERY SYSTEMS -- 9.1 Introduction -- 9.2 Release Mechanisms of Oral Polymeric Dosage Forms -- 9.3 Oral Polymeric Release Modifiers -- 9.4 Manufacturing Technologies and Industrial Applications of Controlled Release -- 9.5 Worked Example -- 9.6 Key Points -- 9.7 Homework Problems -- 10 MUCOADHESIVE DRUG DELIVERY SYSTEMS -- 10.1 Introduction -- 10.2 Factors Affecting Mucoadhesion -- 10.3 Polymer-Mucus Interactions -- 10.4 Mucoadhesion Mechanisms -- 10.5 Mucoadhesive Polymers -- 10.6 Novel Mucoadhesive Materials -- 10.7 Mucoadhesion Testing -- 10.8 Drug Release Studies -- 10.9 Mucoadhesive Dosage Forms -- 10.10 Conclusion -- 10.11 Key Points -- 10.12 Homework Questions -- 11 ENHANCED ORAL DRUG DELIVERY THROUGH METABOLIC PATHWAYS -- 11.1 Introduction -- 11.2 Uptake of Nutrients from the Intestine -- 11.3 Nutrient Transport in the Intestine -- 11.4 Use of Nutrient Transporters for Drug Delivery -- 11.5 Case Study: The Use of the Vitamin B2 Uptake System for Drug Delivery.

11.6 Key Points -- 11.7 Worked Example -- 11.8 Homework Problems -- PART V ADVANCED POLYMERIC DRUG DELIVERY -- 12 STIMULI-RESPONSIVE POLYMER DELIVERY SYSTEMS -- 12.1 Introduction -- 12.2 Temperature-Responsive Polymers for Drug Delivery -- 12.3 pH-Responsive Polymers for Drug Delivery -- 12.4 Reduction/Oxidation (Redox)-Responsive Polymers -- 12.5 Enzymatically Responsive Drug Delivery -- 12.6 Key Points -- 12.7 Homework Questions -- 13 AFFINITY-BASED DRUG DELIVERY -- 13.1 Introduction -- 13.2 Association Constant -- 13.3 Worked Example -- 13.4 Affinity-Based Drug Delivery Systems -- 13.5 Mathematical Modeling of Affinity-Based Systems -- 13.6 Challenges and Future Directions -- 13.7 Key Points -- 13.8 Homework Problems -- INDEX.