Cover image for Epigenetics : Linking Genotype and Phenotype in Development and Evolution.
Epigenetics : Linking Genotype and Phenotype in Development and Evolution.
Title:
Epigenetics : Linking Genotype and Phenotype in Development and Evolution.
Author:
Hallgrimsson, Benedikt, Ph.D.
ISBN:
9780520948822
Edition:
1st ed.
Physical Description:
1 online resource (569 pages)
Contents:
Cover -- Half title -- Title -- Copyright -- Contents -- Contributors -- 1 Introduction -- Benedikt Hallgrímsson and Brian K. Hall -- Part I Historical and Philosophical Foundations -- 2 A Brief History of the Term and Concept Epigenetics -- Brian K. Hall -- 3 Heuristic Reductionism and the Relative Significance of Epigenetic Inheritance in Evolution -- James Griesemer -- Part II Approaches to Epigenetics -- 4 The Epigenetics of Genomic Imprinting: Core Epigenetic Processes are Conserved in Mammals, Insects, and Plants -- Lori A. McEachern and Vett Lloyd -- 5 Methylation Mapping in Humans -- Christoph Grunau -- 6 Asexuality and Epigenetic Variation -- Root Gorelick, Manfred Laubichler, and Rachel Massicotte -- 7 Epigenesis, Preformation, and the Humpty Dumpty Problem -- Ellen W. Larsen and Joel Atallah -- 8 A Principle of Developmental Inertia -- Alessandro Minelli -- Part III Epigenetics of Vertebrate Organ Development -- 9 The Role of Epigenetics in Nervous System Development -- Chris Kovach, Pierre Mattar, and Carol Schuurmans -- 10 Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches -- Lennart Olsson -- 11 Epigenetic Interactions of the Cardiac Neural Crest -- Martha Alonzo, Kathleen K. Smith, and Margaret L. Kirby -- 12 Epigenetics in Bone and Cartilage Development -- Tamara A. Franz-Odendaal -- 13 Muscle-Bone Interactions and the Development of Skeletal Phenotype: Jaw Muscles and the Skull -- Susan W. Herring -- 14 Evolution of the Apical Ectoderm in the Developing Vertebrate Limb -- Lisa Noelle Cooper, Brooke Autumn Armfield, and J. G. M. Thewissen -- 15 Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices -- Boris Kablar -- Part IV Epigenetics in Evolution and Disease.

16 Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking The Functional Matrix Hypothesis -- Daniel E. Lieberman -- 17 Epigenetic Interactions: The Developmental Route to Functional Integration -- Miriam Leah Zelditch and Donald L. Swiderski -- 18 Epigenetic Contributions to Adaptive Radiation: Insights From Threespine Stickleback -- Susan A. Foster and Matthew A. Wund -- 19 Learning, Developmental Plasticity, and the Rate of Morphological Evolution -- Christopher J. Neufeld and A. Richard Palmer -- 20 Epigenetics: Adaptation or Contingency? -- Thomas F. Hansen -- 21 The Epigenetics of Dysmorphology: Craniosynostosis as an Example -- Christopher J. Percival and Joan T. Richtsmeier -- 22 Epigenetics of Human Disease -- Peter D. Gluckman, Mark A. Hanson, Alan S. Beedle, Tatjana Buklijas, and Felicia M. Low -- 23 Epigenetics: The Context of Development -- Benedikt Hallgrímsson and Brian K. Hall -- Index.
Abstract:
Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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