FrontMatter -- Acknowledgments -- Preface -- Contents -- List of Tables and Boxes -- Acronyms -- Executive Summary and Recommendations -- 1 Introduction and Background -- 2 The Regulatory Framework for Protecting Humans in Research -- 3 Scientific Justification for and Conduct of Intentional Human Dosing Studies -- 4 A Risk-Benefit Framework for Assessing Intentional Human Dosing Studies -- 5 Ethical Considerations in the Review of Intentional Human Dosing Studies -- 6 Procedures for EPA Review of Intentional Human Dosing Studies -- 7 EPA's Use of Data from Intentional Human Dosing Studies in Risk Assessment -- APPENDIXES -- Appendix A Values and Limitations of Animal Toxicity Data -- Appendix B Pharmacokinetics and Metabolism of Pesticides -- Appendix C Biographical Sketches of the Members and Staff of the Committee on the Use of Third Party Toxicity Research with Human Research Participants -- Appendix D Biographical Sketches of the Members of the Science, Technology, and Law Panel -- Appendix E Meeting Agendas -- Appendix F Combined Registrants List for All Meetings.