CONTENTS -- AUTHORS' APPOINTMENTS -- FOREWORD -- PREFACE -- ACKNOWLEDGEMENTS -- 1 BURDEN OF CENTRAL NERVOUS SYSTEM INFECTIONS -- Viral infections -- Bacterial infections -- Parasitic infections -- Conclusion -- 2 PATHOGENESIS OF CENTRALNERVOUS SYSTEM INFECTIONS -- Blood-brain and blood-cerebrospinal fluid barriers -- Entry of pathogens into the central nervous system -- Bacteria -- Parasites -- Fungi -- Development of disease: pathogen replication and inflammation in the centralnervous system -- Summary -- 3 THE PRINCIPLES OF MANAGEMENTOF CENTRAL NERVOUS SYSTEMINFECTIONS -- Evaluation and diagnosis -- Emergency management -- Specific treatment -- General supportive care -- Fluid, electrolytes and nutrition -- Raised intracranial pressure -- Adjunctive therapy -- Mechanical ventilation -- Isolation and infection precautions -- The patient's family -- 4 NEUROIMAGING -- Section 1: Bacterial, Fungal, Tuberculous andParasitic Infections -- Imaging modalities -- Imaging clinical syndromes of central nervous system infection -- Section 2: Viral Infections -- Herpes encephalitis -- Arbovirus infections -- Enteroviruses -- Human immunodeficiency virus and associated opportunistic viral infections -- Cytomegalovirus -- Progressive multifocal leukoencephalopathy (PML) -- Other viruses -- Summary -- 5 CONGENITAL INFECTIONS -- Epidemiology -- Clinical manifestations -- Laboratory findings -- Microbiological diagnosis -- Neuroimaging features -- Prevention and treatment of congenital infections -- 6 FEBRILE SEIZURES -- Definition -- Epidemiology -- Risk factors -- Genetics -- Presentation -- Immediate management and diagnostic evaluation -- Lumbar punctureStopping a continuing -- Management -- The long-term outcome of febrile seizures -- 7 VIRAL ENCEPHALITIS AND MENINGITIS -- Enterovirus and parechovirus infections -- Arbovirus encephalitis.

8 HERPES SIMPLEX VIRUS INFECTIONS -- Pathology -- Pathogenesis -- Clinical presentation of herpes simplex virus infections of the brain -- Laboratory considerations for diagnosis -- Therapy -- Conclusion -- 9 JAPANESE ENCEPHALITIS -- History -- The virus -- Transmission and life cycle -- Epidemiology -- Pathogenesis -- Pathology -- Clinical features -- Laboratory diagnosis -- Treatment -- Sequelae -- Prevention -- 10 RABIES -- Epidemiology -- The virus -- Pathogenesis -- Pathology -- Incubation period -- Clinical features -- Laboratory diagnosis -- Prevention of human rabies -- Prevention of rabies in animals -- Public health measures to control rabies -- 11 HIV INFECTIONS -- Epidemiology -- Pathogenesis -- Clinical manifestations -- Complexities of the disorder -- Therapeutic and management issues -- Future directions and new interventions -- Conclusion -- 12 ACUTE BACTERIAL MENINGITIS -- Aetiology -- Epidemiology -- Pathogenesis -- Pathophysiology -- Neuropathology -- Clinical presentation -- Diagnosis -- Differential diagnosis -- Laboratory tests -- Organism identification -- Course and complications -- Neuroimaging in meningitis -- Treatment -- Prognosis -- Prevention -- 13 FOCAL INTRACRANIAL SUPPURATION -- Brain abscess -- Subdural empyema -- Epidural abscess -- Suppurative intracranial phlebitis -- Ventriculoperitoneal shunt infection -- 14 TUBERCULOSIS -- Tuberculous meningitis -- Tuberculoma -- Spinal tuberculosis -- 15 FUNGAL INFECTIONS -- Epidemiology -- Pathogenesis -- Pathology -- Clinical features -- Diagnosis -- Treatment -- Prognosis -- Prevention -- 16 PARASITIC INFECTIONS -- Malaria -- Schistosomiasis -- Toxocariasis -- Trichinosis -- Onchocerciasis -- Nodding syndrome -- Trypanosomiasis -- Cystic echinococcosis -- Paragonimiasis -- Amoebic brain infections -- Summary -- 17 NEUROCYSTICERCOSIS -- Epidemiology.

Life cycle of the parasite -- Pathogenesis -- Clinical manifestations -- Diagnosis -- Differential diagnosis -- Treatment -- Prognosis -- Prevention -- Conclusion -- 18 SPIROCHAETAL INFECTIONS -- Neuroborreliosis -- Leptospirosis -- 19 MYCOPLASMAL INFECTIONS -- Mycoplasma pneumoniae -- Other Mycoplasma species -- 20 RICKETTSIAL DISEASE -- Rickettsia: spotted fever group -- Rickettsia: typhus group -- Ehrlichioses -- Coxiella burnetii (Q fever) -- 21 NEUROLOGICAL CONDITIONSCAUSED BY BACTERIAL TOXINS -- Tetanus -- Botulism -- Diphtheria -- 22 POSTINFECTIOUS DISORDERS -- Pathogenesis -- Disorders of the central nervous system (CNS) -- Disorders of the peripheral nervous system: Guillain-Barré syndrome and variants -- INDEX.