Contents -- Preface -- Acknowledgments -- A Significant Problem -- 1. Dieting "Significance" and the Case of Vioxx -- 2. The Sizeless Stare of Statistical Significance -- 3. What the Sizeless Scientists Say in Defense -- 4. Better Practice: beta-Importance vs. alpha-"Significance" -- 5. A Lot Can Go Wrong in the Use of Significance Tests in Economics -- 6. A Lot Did Go Wrong in the American Economic Review during the 1980s -- 7. Is Economic Practice Improving? -- 8. How Big Is Big in Economics? -- 9. What the Sizeless Stare Costs, Economically Speaking -- 10. How Economics Stays That Way: The Textbooks and the Referees -- 11. The Not-Boring Rise of Significance in Psychology -- 12. Psychometrics Lacks Power -- 13. The Psychology of Psychological Significance Testing -- 14. Medicine Seeks a Magic Pill -- 15. Rothman's Revolt -- 16. On Drugs, Disability, and Death -- 17. Edgeworth's Significance -- 18. "Take 3sigma as Definitely Significant": Pearson's Rule -- 19. Who Sits on the Egg of Cuculus Canorus? Not Karl Pearson -- 20. Gosset: The Fable of the Bee -- 21. Fisher: The Fable of the Wasp -- 22. How the Wasp Stung the Bee and Took over Some Sciences -- 23. Eighty Years of Trained Incapacity: How Such a Thing Could Happen -- 24. What to Do -- A Reader's Guide -- Notes -- Works Cited -- Index.