Lance Preston and the crew of Grave Encounters, a ghost-hunting reality television show, are shooting an episode inside the abandoned Collingwood Psychiatric Hospital where unexplained phenomena has been reported for years. In the name of good television, they voluntarily lock themselves inside for the night and begin a paranormal investigation, capturing everything on camera. They soon realize that the building is not only haunted, it's alive, and it has no intention of ever letting them leave.