The last man on earth is not alone. Somehow immune to an unstoppable, incurable virus, military virologist Robert Neville is now the last human survivng in New York City. He believes he may be the last human alive in the world. Mutant plague victims lurk in the shadows. They watch Robert's every move and wait for him to make a fatal mistake. Robert is driven by only one remaining mission - to find an antidote using his own immune blood. But, he is outnumbered and quickly running out of time.