Cu-BTC is synthesized from Copper(II) nitrate and benzene-1,3,5-tricarboxylic acid and it is one of the most common metal organic framework which is used for catalysis, sensing, controlled release, separation and storage processes. The application areas of Cu-BTC could be increased by deposition on different surfaces. Cu-BTC is positively charged and to deposit Cu-BTC on a surface, the surface must have negative charge. The most common natural material with negative charge is cellulose. Raw pulp fibers, cotton and viscose fabrics are rich in terms of cellulose, so they were used as cellulose source. The aim in this study is to deposit Cu-BTC on pulp fibers, cotton and viscose fabrics and then, to investigate their sensing properties. In order to investigate whether Cu-BTC was deposited on cotton, pulp, and viscous fibers or not, a characterization study was carried out to investigate their properties. In this context, XRD, SEM, FT-IR, ATR-IR analysis were performed. As a result of the characterization study, it was concluded that the Cu-BTC was deposited on the pulp, cotton fibers, and viscous successfully. The Cu-BTC deposited substrates showed sensing activity against humidity and NH3 gas.