Precise estimation of the sediment transport and settling velocity of particle in turbulent flows is required for many engineering applications including modeling of the transport of suspended sediments and the transport of particle pollutants. This study presents an approach for modification of an existing CFD Model for sediment transport in turbulent flow based on field measurements. In the first part, synchronized 3-D velocity and temperature time series were monitored at Büyük Menderes River in Turkey where the data were utilized to characterize the turbulence characteristics and model particle – fluid interaction. Sieve and hydrometer analysis were obtained from earlier studies to understand and modify sediment transport under different conditions via ANSYS Fluent programme. The second part of the study involved numerical modeling of hydrodynamics via 3D CFD model in the selected portion of a river body through use of field measurements conducted at the study site. The k-ω turbulence model found to be the best suited when such flow around a structure as piers or flow through a water intake is considered. Effect of particle size, concentration and modeling approach for particle motion are also investigated and Rossin Rammler Logarithmic Distribution and multiphase modeling approach was the most appropriate methods. This study involved development of an approach to modify drag force on sediment particles using turbulence characteristics in the Fluent solver as well.