This PhD thesis aims to examine the fatigue behavior of sandwich panels fabricated from adhesively bonded aluminum honeycomb core and carbon fiber reinforced polymer composite face sheets. Initially, sandwich panels were manufactured with three different amounts of adhesive in their interface. Static flexural behavior was characterized with three-point bending tests. Load-displacement curves and static flexural failure modes were obtained and utilized to compare the static flexural behavior of fabricated sandwich. Fatigue behavior of sandwich panels were characterized with the three-point bending fatigue tests. Stiffness degradation curves were used to identify the failure cycles of sandwich panels. Fatigue failure modes and S-N curves were obtained to find out the effect of amount of adhesive on fatigue behavior of sandwich panels. The other study within this thesis was made to investigate the effect of core thickness on the fatigue behavior of the sandwich panels based on aluminum honeycomb core and carbon fiber reinforced polymer composite face sheets. Sandwich panels were fabricated by using three different aluminum honeycomb core thickness. Static flexural tests were carried out to determine the static flexural behavior of developed sandwich panels. Load-displacement curves and failure modes were obtained from flexural tests. In addition to this, core shear tests were performed to investigate the core shear strength of the honeycomb cores with different core thickness. Effect of core thickness on fatigue behavior of sandwich panels were characterized with fatigue failure modes and S-N curves. Stiffness degradation method was used to determine the fatigue failure cycles of the sandwich panels.